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Asthma does not appear to increase the risk for humans Contracting COVID-19 or affect its severity, according to a team of researchers at Rutgers University.

“Reported of advanced age and conditions such as heart disease, high blood pressure, chronic obstructive pulmonary disease, diabetes and obesity risk factors for the development and progression COVID-19″, – said A. Reynold Panettieri Jr., pulmonary intensive care physician and Director of the Rutgers Institute for translational medicine and science and co-author of an article published in Journal of Allergy and clinical immunology. “However, people with asthma, even persons with reduced lung function who are undergoing treatment for inflammation—it seems that the asthma to be worse than the SARS-cov-2 than non-asthmatic. There are limited data why this is so—if it is physiological or the result of treatment to control the inflammation.”

Panettieri discusses what we know about asthma and inflammation and are important issues that still need to be answered.

How can awareness of SARS-cov-2 affect the health of people with asthma?

Because we focused on the effects COVID-19 for people in vulnerable groups, persons with asthma may be Hyper-vigilant about personal hygiene and social distancing. Social distancing can improve asthma control, as people who isolated themselves too not as susceptible to seasonal triggers that include allergens and respiratory viruses. There is also evidence that people were more careful, taking their medications for asthma during a pandemic which can contribute to overall health.

What is the effect of inhaled steroids on COVID-19 results?

Inhaled glucocorticosteroids, which are widely used for protection against asthma attacks, it also can reduce the ability of the virus to establish an infection. However, studies have shown that steroids can reduce the immune response and worsen the inflammatory process. Steroids has also been shown to delay the clearance of virus and SARS—like mers to SARS-cov-2—from the respiratory tract and thus may worsen COVID-19 results. Future research should address whether inhaled steroids in patients with asthma or allergies to increase or decrease the risks of SARS-cov-2 infection, and whether these effects differ depending on the type of steroid.

How does age play a role in how asthma patients respond to exposure to the virus?

Sensitivity to and severity COVID-19 infection increases with age. However, since patients with bronchial asthma tend to be younger than those reported by high-risk, age-adjusted studies could help us to better understand that age is a factor in explaining why patients with asthma may not be at a greater risk for infection.

Children and young adults with asthma suffer mostly from allergic inflammation, while in older people who experience the same type of airway inflammation can also suffer from eosinophilic asthma is a more severe form. In these cases, people experience abnormally high levels of white blood cells that helps the body to fight infection, which can cause inflammation in the Airways, sinuses, nasal passages and the lower respiratory tract, which makes them potentially a greater risk for a serious case COVID-19.

In addition, the enzyme attached to the cell membranes in the lungs, arteries, heart, kidneys and intestines, which has been shown to be the entry point for SARS-cov-2 in the cells increases in response to the virus. This enzyme is also thought to be useful in cleaning other respiratory viruses, especially in children. How this enzyme affects the ability of SARS-cov-2 to infect people with asthma is still unclear.

As conditions in addition to asthma affects the risk of infection?

Asthma, usually associated with a much smaller number of other conditions than chronic obstructive pulmonary disease or cardiovascular diseases. If SARS-cov-2 is a disease that causes dysfunction of cells that line blood vessels throughout the body, then diabetes, heart diseaseobesity and other diseases associated with this condition can make people more susceptible to the virus than those who are asthmatic. However, older persons with asthma who also have high blood pressurediabetes or heart disease perhaps such instances COVID-19 asthmatics with those conditions.

Asthma is not a risk factor of deterioration COVID-19: study

More information:
The Reynold A. Panettieri et al, asthma and COVID: what are the important questions? Journal of Allergy and clinical immunology: in practice (2020). DOI: 10.1016/j.jaip.2020.06.008

Asthma does not seem to increase the severity COVID-19 (2020, July 6)
retrieved 6 July 2020

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