J&J publicizes PPP for Investigational Prophylactic HIV Vaccine

Janssen’s mosaic vaccine is designed as a worldwide vaccine with the objective of stopping infections from the big selection of viral strains chargeable for the HIV pandemic

Johnson & Johnson has introduced that Janssen Vaccines & Prevention B.V., one in all its Janssen Pharmaceutical Firms, along with a consortium of worldwide companions are making ready to launch Mosaico, the primary large-scale Part three efficacy research of Janssen’s investigational mosaic-based HIV-1 preventive vaccine. Janssen’s mosaic vaccine is designed as a worldwide vaccine with the objective of stopping infections from the big selection of viral strains chargeable for the HIV pandemic.

The Nationwide Institute of Allergy and Infectious Ailments (NIAID), a part of the Nationwide Institutes of Well being (NIH), the HIV Vaccine Trials Community (HVTN) based mostly on the Fred Hutchinson Most cancers Analysis Middle, and the U.S. Military Medical Analysis and Growth Command (USAMRDC) are becoming a member of forces with Janssen to advance the potential world vaccine. The general public-private partnership’s plans for Mosaico will likely be described in additional element on the 10th IAS Convention on HIV Science (IAS 2019) in Mexico Metropolis, together with new late-breaking information concerning the mosaic-based vaccine routine to be studied in Mosaico.

Paul Stoffels, M.D., Vice Chairman of the Govt Committee and Chief Scientific Officer, Johnson & Johnson stated, “Our imaginative and prescient at Johnson & Johnson is to develop a preventive vaccine that may be deployed wherever, worldwide, to halt the HIV epidemic. No single group can deal with this historic problem alone. By working with our world companions and leveraging cutting-edge applied sciences, we’re optimistic that we will obtain an HIV vaccine in our lifetime.”

Mosaico (HPX3002/HVTN 706) can have a goal enrollment of three,800 people in eight international locations throughout North America, South America and Europe. It’s anticipated to begin later in 2019. Performed at roughly 55 scientific websites worldwide, the research will consider Janssen’s mosaic-based HIV vaccine in males who’ve intercourse with males (MSM) and transgender folks.

“We’re decided to develop a globally efficient HIV vaccine to scale back the trajectory of the estimated 1.5 million new HIV infections which might be occurring,” stated Larry Corey M.D., Principal Investigator of the HVTN, virologist, and president and director emeritus on the Fred Hutchinson Most cancers Analysis Middle in Seattle.

Johan Van Hoof, M.D., International Therapeutic Space Head, Vaccines, and Managing Director, Janssen Vaccines & Prevention B.V., Janssen Pharmaceutica NV stated, “The seek for a vaccine started the second HIV was first recognized over 35 years in the past, however there have been many challenges alongside the way in which as a result of distinctive properties of this virus, together with its world genetic variety. Janssen is dedicated to advancing scientific trials to assist construct an HIV-free future. With every new research we’re working to optimize the mosaic-based vaccine routine.”

Mosaico would be the second, and largest, efficacy research for Janssen’s investigational HIV vaccine. The primary efficacy research, the proof-of-concept Part 2b scientific trial often known as Imbokodo (HPX2008/HVTN 705), is at the moment evaluating a mosaic-based vaccine routine in 2,600 younger girls (aged 18-35) throughout 5 southern African international locations.


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