Tag Archives: asthma

Edwin Kim, MD, MS: Development of Food Allergy Research | Instant News

As discussed previously, new data from the American Academy of Allergy, Asthma & Immunology (AAAAI) 2021 Virtual Sessions shows sublingual immunotherapy (SLIT) in children under five with peanut allergy results in significant desensitization to allergens and a sustained inresponsiveness to allergen exposure several months after one ends. time. Daily SLIT.

Research presented by Edwin Kim, MD, MS, of the University of North Carolina School of Medicine, proves that even younger patients benefit more and last longer.

In the second segment Interview with HCPLive, Kim discusses the next steps of research and application of food allergy immunotherapy.

HCPLive: Something that is highlighted in the AAAAI discussion every year now is the risk of cross-allergic and cross-inflammatory disease. As you said, the patient may suffer from multiple allergies. They can also suffer from asthma, allergies, atopic dermatitis, and others.

We talked a lot about effectively treating something like asthma and what benefits it has for other conditions. But if we were to say that we could treat food allergies better at this early age, how would that affect other comorbid conditions that children often face?

Kim: I mean, that’s a fantastic question. And sadly, I didn’t know that we had a clue at all. I would say that for pollen allergies, your usual environmental allergy, there is a thought that starting to focus on allergy shots younger so that it can prevent the onset of asthma. I don’t know if we have any common sense when it comes to food allergies, whether we would have the same preventive effect on other diseases. We hope so. I personally haven’t seen the data to back it up at this point.

You mentioned the Stanford nut allergy research that comes up quite frequently. Is there anything else you look forward to regarding developments in the field of food allergy treatment?

Kim: First, with our sublingual research: PALFORZIA’s getting that approval is huge, right? I see this as validating food allergy as a real problem, something that needs treatment. And it also, for me, validates the concept of immunotherapy as something that actually works and can provide protection.

At the same time, I think COVID-19 has made it clear that oral immunotherapy is difficult. And it won’t be for everyone. I think it’s important not only to research the application of this treatment to other foods and to make them last longer, but also to find ways to make them more practical. So, I was looking for that. I would love to see questions around, ‘Do we have to do this every day? Is this something that can be a once a week type of treatment? Once a month?’

You know, just thinking from the patient’s point of view: how do we actually make this accessible to the patient? We know it’s working now, and it’s out there. But we are looking for a verbal, hopefully sublingual, and epikutan way. Is there a way forward for that? Because it will represent a simplified version of immunotherapy which may be a good choice for some patients.

So, I’m really looking at the future for not only improvements to science, but also options for patients, because at this point, nothing looks like it’s going to be a cure. With that in mind, any treatment that fits the patient’s goals, I think it will be very important if we are to make a real difference to food allergies.

This basically sounds like the next step of any new therapy: what’s the optimization? What guarantees patient benefit and compliance?

Kim: Correct. I think it’s an amazing time in our field right now. And I think the next few years will really last, because I think the doors are now wide open for new treatments.


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Shares in Italian highway group ASTM surged in a bid to make the company private | Instant News

MILAN, Feb 22 (Reuters) – ASTM shares surged 27% on Monday, lifted by a buyout offer from a top Italian motorway group investor who wants to take the company private and revamp it.

Nuova Argo Finanziaria (NAF), which holds a 42% stake in ASTM, said at the weekend it would offer 25.60 euros per share in a new vehicle to buy minority investors at an outlay of up to 1.7 billion euros ($ 2 billion).

This represents a premium of 28.8% over ASTM’s official closing price on Friday.

The NAF said it plans to transform business, adding it will be easier to pursue reorganization of unlisted companies.

The Italian Gavio family are major investors in the NAF along with the infrastructure arm of French private equity firm Ardian.

Ardian agreed to invest in ASTM just days before a highway bridge operated by toll road company Atlantia collapsed in August 2018, killing 43 people.

In response to the tragedy, the Italian government has stepped up investment oversight by concessionaires, establishing a new body to monitor safety standards.

$ 1 = 0.8269 euros Report by Elisa Anzolin, written by Valentina Za; Edited by Kirsten Donovan


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Hospitalizations for Food Anaphylaxis Threefold, But Deaths Decreased | Instant News

UK hospital admission rates for food-induced anaphylaxis more than tripled over the 20 years from 1998 to 2018, but the case fatality rate fell by more than half, the researchers report in BMJ.

“Cow’s milk is increasingly being identified as an allergen to fatal food reactions, and is now the most common cause of fatal anaphylaxis in children,” writes Alessia Baseggio Conrado, PhD, a biochemist from the National Heart and Lung Institute at Imperial College London, United States. Kingdom, and colleagues. “Further education is needed to highlight the specific risks that cow’s milk poses to allergic people to raise awareness among the food business.”

While recognition of the risks posed by peanut allergies has increased, people think dairy allergies are mild, says senior author Paul. J. Turner, BM BCh, PhD, allergist / immunologist at Imperial College. “This often occurs in very young children, but school-age children who still have a milk allergy tend to have a larger allergy profile, often with other allergies, including asthma, “Said Turner Medscape Medical News. “Additionally, milk is very common in our diet, and you don’t need a lot of milk to reach a decent dose of allergens.”

During the study period, 101,891 people were hospitalized for anaphylaxis; 30,700 cases (30%) were coded as being triggered by food.

This food-related income showed an increase from 1.23 to 4.04 per 100,000 population per year, with an annual increase of 5.7% (95% CI, 5.5 – 5.9; P. <0.001), write the authors.

The greatest jump was among children under 15, whose enrollment increased from 2.1 to 9.2 per 100,000 population per year, an annual increase of 6.6% (95% CI, 6.3 – 7.0) . The annual increase was 5.9% (95% CI, 5.6 – 6.2) among people aged 15 to 59 years and 2.1% (95% CI, 1.8 – 3.1) among people those aged 60 years and over.

Researchers used data from England, Scotland, Wales, and Northern Ireland to track temporal trends and age and sex distribution for admissions to hospital admissions whose primary diagnosis was anaphylaxis due to food and non-food triggers. These data are compared with nationally reported deaths.

Over a 20 year period, 152 deaths were associated with possible food-induced anaphylaxis. During that time, the case fatality rate for confirmed fatal food anaphylaxis fell from 0.7% to 0.19% (rate ratio, 0.931; 95% CI, 0.904 – 0.959; P. <0.001) and fell to 0.30% for suspected fatal food anaphylaxis (rate ratio, 0.970; 95% CI, 945 - 0.996; P. = 0.024).

Between 1992 and 2018, at least 46% of all anaphylactic deaths were thought to be triggered by peanuts or tree nuts. Among school-aged children, 26% of deaths from anaphylaxis are caused by cow’s milk.

Not surprisingly, during the study period, there was a 336% increase in prescriptions for adrenaline autoinjectors. Such prescriptions increase by 11% per year.

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The data extends the findings of Turner and colleagues reported for England and Wales in 2014 about the entire population of England and in line with epidemiological trends in hospital admissions for anaphylaxis in the United States and Australia.

The investigators say better recognition and management of anaphylaxis could partially explain the reduction in mortality, but the increase in hospitalizations remains confusing. “Whether an actual increase in the prevalence of anaphylaxis has occurred (rather than a decrease in the threshold for admitting patients with anaphylaxis) is unclear due to a lack of evidence for an increase in the prevalence of food allergy in the UK (and elsewhere) over the same time period,” they wrote.

Ronna L. Campbell, MD, PhD, an emergency doctor at the Mayo Clinic in Rochester, Minnesota, has noted a similar trend in the United States. “Perhaps the introduction and diagnosis of anaphylaxis has increased, so the drug administration is earlier epinephrine, “Said Campbell Medscape Medical News. “So, as cases increased, earlier recognition and treatment resulted in reduced mortality.” He is not aware of any new guidelines recommending increased hospitalizations that would explain the confusing increase in admissions.

According to the study authors, the clinical criteria used to diagnose anaphylaxis in the UK did not change during the study period. Although national guidelines recommend that hospitalization of children under 16 years of age suspected of having anaphylaxis were introduced in 2011 and may have increased patient admissions, the year-over-year rate of increase has persisted since 2014. “Therefore the increase over the past five years cannot associated with the impact of the guide, “they wrote.

The study was funded by grants from the UK Medical Research Council and the UK Food Standards Agency. Two co-authors have disclosed financial links to industry outside of the jobs that are sent. Conrado did not disclose the relevant financial relationships.

BMJ. Published online February 17, 2021. Full text

Diana Swift is a medical journalist based in Toronto.

Follow Medscape on Facebook, Indonesia, Instagram, and Youtube.


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Air pollution is listed as the cause of death of a 9 year old British girl living in a toxic environment | Instant News

A coroner in London has determined that a 9-year-old black girl, who died in 2013 of asthma, also died from exposure to fatal air pollution. Decision making Ella Adoo-Kissi-Debrah first person in Great Britain to have a “polluted environment” listed as a cause of death on his death certificate.

“I would conclude that Ella died of asthma, which was caused by excessive exposure to air pollution,” said Southwark Coroner Court assistant coroner. Philip Barlow after a two week checkup, according to the British newspaper Independent. The causes of death will be recorded as acute respiratory failure, severe asthma, and exposure to air pollution.

The determination outlines the increasing dangers of environmental failure, especially in communities where children are constantly exposed to it. According to one World Health Organization study, more than 90 percent of children under the age of 15 – about 1.8 billion – worldwide breathe polluted air every day.

RELATED: Earth Day Serves as Reminder of Link Between Black Environmental Gap and Health and COVID-19

Ella, who lived in Lewisham in southeast London, died after a severe asthma attack. Prior to his death, he had several seizures and had to be hospitalized more than 30 times over three years. Independent reported.

At six years of age, she had to enter a medically induced coma to stabilize it. “It gets to the point that we are just waiting for the next one [seizure] happened, “her mother, Rosamund Adoo-Kissi-Debrah, said during the examination.

An earlier examination ruling from 2014 said Ellla died of acute respiratory failure, but did not identify air pollution as a factor. It was ruled out when new evidence emerged of toxic air levels near his home. A 2018 report found levels of illegal pollution near the family home were found at the monitoring station, which played a role in his asthma. according to the BBC.

RELATED: Survey Found Majority of Black People Admitted That Pollution Is A Serious Threat

Sir Stephen Holgate, professor of immunopharmacology at the University of Southampton, testified during the examination that Ella’s condition and her environment put her at “enormous” risk. He wrote a 2018 report showing that the monitoring station continuously recorded the amount of unlawful air toxins for the three years prior to his death.

“Ella’s mother was not informed about the health risks of air pollution and its potential to worsen asthma,” said Barlow, noting that authorities failed to recognize the dangerous amount of nitrogen dioxide (NO2) in the air near their home, which was missing. WHO and European Union standards. “If he’s given this information, he will take steps that might prevent Ella’s death.”

Ella’s mother said she knows nothing about nitric oxide, but she thinks vehicle pollution could play a role in the child’s illness because their home is close to one of London’s busiest highways.

Adoo-Kissi-Debrah said he wants more people to be educated about the dangers of air pollution, which continues to harm London’s children.

We are getting the justice for him which he deserves, “he said, according to the BBC. “But it’s also about other kids, as we walk around our cities with high levels of air pollution.”


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Research shows that night shift workers have a third increase in asthma risk | Instant News

If a person suffers from severe asthma, their risk will increase by a third Permanent night shifts, a new study shows.

Researchers say that the results of the survey published online by the BMJ magazine Thorax have potential “far-reaching implications” because about one-fifth of employees work on permanent or shift night shifts.

The study, led by the University of Manchester and the University of Manchester NHS Foundation Trust, compared the effects of normal work 9 to 5 or day shifts and night shifts on the diagnosis, lung function and symptoms of asthma.

They used the medical, lifestyle and employment information provided by more than 286,000 people in paid employment or self-employment between the ages of 37 and 72 in the UK between 2007 and 2010.

Most participants (83%) work on time, the rest work in shifts, and about half of them include night shifts.

Approximately 5% of all study participants have asthma; Nearly 2% of them have moderate to severe symptoms.


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