Tag Archives: Career

Octapharma AG: Final data from the published NuProtect study on the immunogenicity of Nuwiq® in previously untreated patients with severe hemophilia A | Instant News


LAUGH, Switzerland, 22 February 2021 / PRNewswire / –Octapharma AG today announced the final results of the NuProtect study on Nuwiq immunogenicity® on previously untreated patients (PUP) with severe hemophilia A has been published in leading medical journals Thrombosis and Hemostasis (Liesner RJ et al. “Simoctocog Alfa (Nuwiq®) in a Previously Untreated Patient with Severe Hemophilia A: The End Result of the NuProtect Study ” https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0040-1722623).

The NuProtect Study (NCT01712438; EudraCT 2012-002554-23) is a prospective, multinational, open-label, uncontrolled phase III study initiated in March 2013 to assess the immunogenicity, efficacy and safety of Nuwiq®. The study recruited patients of all ages and ethnicities at 38 locations in 17 countries and followed patients for 100 days or up to 5 years. With a enrollment of 110 patients, the NuProtect study is the largest clinical study to investigate a single product in true PUPs.

Of the 105 PUPs that could be evaluated with severe hemophilia A who received Nuwiq® for prevention and treatment of bleeding:

  • 16.2% (17/105) of patients developed high titer inhibitors
  • 10.5% (11/105) of patients developed low titer inhibitors, five of which were transient
  • 26.7% (28/105) of patients developed any inhibitor

The NuProtect study shows that there is a low risk of inhibitor development in PUPs starting treatment with Nuwiq®, “comments Dr. Ri Liesner, NuProtect study research coordinator and clinician at Great Ormond Street Hospital for Children at London, England. “This data shows Nuwiq® may be an attractive option for people recently diagnosed with severe hemophilia A, who are children and constitute a subset of susceptible patients.. “

The development of inhibitors into replacement factor VIII (FVIII) is of concern to doctors, as well as for patients and their families, especially when they first start treatment. Inhibitors make FVIII therapy ineffective and limit treatment options.

These data complement the wealth of clinical experience in hemophilia A patients receiving Nuwiq® for the treatment and prevention of bleeding.

“Nuwiq® developed in human cell lines with the aim of minimizing the risk of inhibitors in PUPs,said Larisa Belyanskaya, Head of Hematology, MOM Octapharma. “We are delighted to share this positive data, which reflects this goal and which we hope will contribute to addressing this major treatment challenge. ”

We know that hemophilia A patients face life-long treatment decisions, “commented Olaf Walter, Board Member at Octapharma. “This data highlights Nuwiq’s potential® to reassure PUP and their families when they start treatment. This publication brings us closer to Octapharma’s goal of enabling all patients to lead healthy lives. “

Earlier this year the FDA approved the inclusion of immunogenicity data from the NuProtect study at Nuwiq.® Prescribing Information. Further publication of another analysis of the NuProtect study is planned.

Professor Anthony Chan, co-author of the publication and Professor of Paediatrics at McMaster University, Canada, said: “Congratulations and thanks to Octapharma for developing Nuwiq, sponsoring trials and providing excellent therapy for hemophilia A.

Octapharma would also like to thank all participating centers, as well as their patients and caregivers, for their contributions to this research.

About Nuwiq®

Nuwiq® (simoctocog alpha) is a 4th generation recombinant factor VIII (rFVIII) protein, produced in human cell lines without chemical modification or fusion with other proteins.1. It is cultivated without additives of human or animal origin, without antigenic non-human protein epitopes and has a high affinity for von Willebrand factor.1. Nuwiq® treatment was assessed in seven comprehensive clinical trials that included 201 previously treated patients (PTP; 190 people) with severe hemophilia A, including 59 children.1. Nuwiq® available in 250 IU, 500 IU, 1000 IU, 2000 IU, 2500 IU, 3000 IU and 4000 IU presentations2. Nuwiq® approved for use in the treatment and prophylaxis of bleeding in patients with hemophilia A (congenital FVIII deficiency) in all age groups2.

1. Lissitchkov T et al. There is Adv Hematol 2019; 10: 2040620719858471.
2. Nuwiq® Summary of Product Characteristics.

About Hemophilia A

Hemophilia A is an X-linked hereditary bleeding disorder caused by factor VIII (FVIII) deficiency which, if left untreated, can lead to bleeding in the muscles and joints and consequently to arthropathy and severe morbidity. This disorder affects about one in every 10,000 men worldwide. Prophylaxis with FVIII replacement therapy reduces the number of bleeding episodes and the risk of permanent joint damage.

About Octapharma

Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein producers in the world, developing and producing human proteins from human plasma and human cell lines.

Octapharma employs more than 9,000 people worldwide to support patient care in 118 countries with products in three therapeutic areas: Hematology, Immunotherapy and Critical Care.

Octapharma has seven R&D locations and six state-of-the-art manufacturing facilities at Austria, France, German, Mexico and Sweden, and operates more than 160 plasma donation centers Europe and United States of America.

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SOURCE Octapharma AG

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Sixth grade student CMS organizes an Ag Career Fashion Show | Public | Instant News


The sixth grade agriscience class, Food, Forests and Wildlife, holds an Agricultural Career Fashion Show on February 8. Each student chooses an agricultural career that suits their interests and then researches that career, learning about the types of skills they will need for that career, salary, what they will wear to work and other interesting facts. They then dress up in props to represent that farming career and march towards the music and party lights.

Careers reviewed include dairy farmer, sales and marketing staff, plant scientist, animal scientist, and veterinarian. Several students completed the Ag Explorer Careers survey and were matched with careers in the agricultural industry based on their personal interests. Some were surprised by their matches – such as nuclear engineers, truck drivers, and graphic designers.

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Imran Khan’s ascent to the top of politics was long and arduous | Instant News


(MENAFN – NewsIn.Asia) Colombo, February 20 (newsin.asia): Imran Khan had an illustrious career in international cricket for two decades from the 1970s. He developed a good reputation worldwide through his charismatic personality and charity work. The charismatic captain led Pakistan to World Cup victory in 1992.

But Khan struggled for years to turn popular support into electoral gains. He launched Pakistan Tehreek-e-Insaf (PTI) in 1996. His party won the 2018 General Elections and he became Prime Minister of Pakistan after 22 years of political struggle, shows the release of the Pakistan High Commission.

The Pakistani PM will visit Sri Lanka on February 23 and 24 where he and his distinguished entourage will meet Sri Lankan political leaders and businessmen. Khan will address the Pak-Sri Lanka conference on Trade and Development.

Imran Khan’s economic vision for Pakistan is alluring. Khan works hard to improve the lives of the poor. He promised a “new Pakistan” in the 2018 General Election. Imran promised the country for a uniform education system, launched a health card scheme, eradicating corruption, enhancing the tax culture, independence of Pakistan, creating job opportunities, strengthening federations, reforming the police, increasing investment and tourism, strengthening the agricultural sector by imposing agricultural emergencies, and protecting the female population. He is on the right track to fulfill his promise with the nation.

Prime Minister Imran Khan’s government has dealt with the economic impact of the pandemic with an effective and successful strategy during difficult times. 2020 is known as a fairy tale of challenge globally, but for Pakistan, under PM Imran Khan, it has proven to be a ‘success and development story’ even during the coronavirus pandemic.

The year 2020 tells of a stable economic journey, various development and welfare projects, and extraordinary achievements in the field of foreign policy. Khan’s government has reached significant milestones during 2020 along with the Prime Minister’s series of New Year’s resolutions for 2021.

Khan not only achieved on the domestic front but also strived for the advancement of the world. Prime Minister Imran Khan, in his address at the 75th UN General Assembly (UNGA), highlighted global issues including climate change, money laundering, pandemics, Islamophobia and human rights abuses. He called on the United Nations to play its role in fighting racism and ensuring the implementation of its own resolutions for global peace and stability.

Imran Khan is a philanthropist. He is endowed with natural leadership and the ability to amass great wealth. He has a great talent for management in all walks of life, especially in business and financial matters, where he contributes to a larger vision, goals and long-term goals. He understands the material world, and knows intuitively what makes nearly any company successful. Business, finance, real estate, law, science, publishing, and management of large institutions are some of the most suitable vocational fields for Imran. He is naturally drawn to positions of influence and leadership, politics, social work, and teaching among the many other fields where his abilities shine.

PM Imran Khan’s twenty-two years of political struggle can be compared to a thrilling test cricket match, full of twists and turns. After going through a long struggle, he succeeded in the 2018 elections. PM Imran Khan’s government has managed to perform well in the foreign affairs arena as well. Critical in this regard is Khan’s personal charisma on the international stage and his close coordination with all state institutions.

During the 1990s, Khan also served as UNICEF’s Special Representative for Sport and promoted health and immunization programs in Bangladesh, Pakistan, Sri Lanka and Thailand. While in London, he also worked with Lord’s Taverners, a cricket charity. After retiring from cricket and before joining politics Khan focused his efforts solely on social work. In the early nineties, she founded the Shaukat Khanum Memorial Trust, a charity organization that bears the name of her mother, Madame Shaukat Khanum. As his first venture, Khan founded Pakistan’s first and only cancer hospital, built using donations and funds in excess of $ 25 million, raised by Khan from around the world.

Khan also founded a technical college in Mianwali District during April 2018 called Namal College. It was built by the Mianwali Development Trust (MDT), and is an associate college of the University of Bradford. The Imran Khan Foundation is another welfare work, which aims to help needy people across Pakistan. It has provided assistance to flood victims in Pakistan.

President Rajapaksa is familiar with Pakistan where he has attended a number of military courses at Pakistani military training institutes. Meanwhile Prime Minister Mahinda Rajapaksa also has deep ties with Pakistan. Imran khan has visited Sri Lanka several times and has many fans in the Island Country. Prime Minister Khan’s upcoming visit will be a great opportunity for the leaders of the two countries to establish meaningful and beneficial bilateral relations for the people of Sri Lanka and Pakistan which will further strengthen relations between the two friendly countries.

Imran Khan Politics of Sri Lanka’s Struggle Social Service

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Racing: New Zealand horses Aegon and Probabeel produce gold watches in Australia | Instant News


Sports

Aegon claims victory in Australia. Photo / Getty

Aegon gave young coaching star Andrew Forsman one of the most emotional victories of his career with a bizarre Australian debut on Saturday to close off a golden hour for New Zealand racing.

Cambridge Galloper overcame a slow start to beat most of Sydney’s elite three-year-olds at the A $ 400,000 Hobartville Stakes in Rosehill just an hour after Matamata mare Probabeel dazzled at A $ 500,000 Futurity in Caulfield.

Probabeel is stunning after sitting three times wide throughout the race and stepping clear at the top of the straight to hold the Arcadia Queen, with the pair now dominating the market for The Valley’s A $ 5 million All-Star Mile in three weeks.

It was the best win of her career from Probabeel, but as beautiful as it was, it should come as no surprise to racing fans on both sides of Tasman as she continues on her path to becoming a great mare.

If she earns an All-Star-worthy gateway at The Valley on March 13, she can award another young Kiwi training star at Jamie Richards with the richest win ever earned by a native New Zealand-trained on Australian soil.

But it was Aegon who would surprise more than some Australians because he not only beat their Guinea rivals, he gave them a head start and hit them.

Coach Forsman also owns a stake in Aegon’s holdings and while he and training partner Murray Baker are used to winning elite-level races for other people, beating Sydney on one of his horses is a different matter.

“I don’t think I got too emotional after the race for a while,” said Forsman.

“I literally watched the race on my phone pull over the side of the road on my way home from Ellerslie.

“I got very emotional so I’m glad I was alone.”

Aegon is owned by the Zame family where Forsman and Baker won the ATC Derby with Jon Snow and while he could possibly win the classic in April, Forsman admits Doncaster against horses older than a mile may be a better fit.

The win capped a big day for the Baker / Forsman side after they won the Avondale Cup at Ellerslie with Robusto, where they also finished third with Star Tsar, both now heading for the Auckland Cup on March 13.

Another feature in Ellerslie, the $ 120,000 Avondale Guineas, is omitted by the favorite Rocket Spade, who, like many others, is racing to the Vodafone Derby on March 6.

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New Hybrid Job Expectations from UK Employees | Instant News


LONDON – (BUSINESS WIRE) – 18 Feb 2021–

2020 has been a defining year for digital transformation in the workplace. The urgent shift to remote work has seen the world undergo two years of digital transformation in two months. New research from Microsoft Surface has examined the impact of this transformation on the UK workforce, finding that employees are happier, but are under more pressure to work from home – even though nearly 9 in 10 (87%) employees report their business has adapted to a hybrid. work.

This press release features multimedia. Check out the full release here: https://www.businesswire.com/news/home/20210218005065/en/

Howard Lewis, Surface Business Group Lead, Microsoft UK, at the release of Work Smarter to Live Better: new research that uncovers UK workforce expectations regarding hybrid jobs (Graphic: Business Wire)

Research, Work Smarter to Live Better, saw more than 4,000 UK office workers surveyed online via a YouGov survey, in addition to in-depth interviews with senior business leaders from across the UK. These findings have been analyzed in partnership with CIPD, the professional body for HR and human resource development. person

The mass adoption of hybrid work requires UK organizations to examine everything from employee benefits to training, roles and responsibilities and the technology at their disposal in order to operate successfully. Research has found:

  • The majority of UK organizations have stepped forward to prepare and support their workforce. 65% of employees agree that their organization has provided everything they need to work effectively from home. Of those whose organizations have a formal work from home policy, 63% disagreed that they felt pressure to return to the office, even though guidelines were permitted.
  • The new way of working has provided opportunities for the British workforce to live life at a different pace. 55% used their lunch break to focus on their personal lives and 56% reported increased levels of happiness working from home
  • However, many employees reported that they were doing more work than before. Nearly one in three (30%) reported an increase in their working hours while working from home, and more than half (53%) agreed that they felt they had to be available at all times.
  • As a result of this new pressure, for more than a third of people surveyed (36%), mental health and resilience resources were the most popular choices in choosing training to build remote work skills.
  • Employees miss seeing their coworkers in person, and opportunities for social interaction are a key driver of people’s decisions to go to the office if guidelines allow. For the majority (65%), socializing is what they miss most when working remotely.

Although companies in the UK are currently using a digital-first approach, few plan to have 100% of a long-term remote workforce. The most likely scenario is that most organizations will adopt a hybrid work model, where the workforce is divided between working remotely and working in an office. This discovery means organizations and employees must adapt to support hybrid work in the long term.

“The COVID-19 pandemic has sparked the largest homework experiment we’ve seen in the UK. However, this is not working at home during normal times – many of these experiences have been treated as homeworkers and many people have faced additional stresses and anxieties.Therefore, it is very important for line managers to make sure people don’t overwork and to provide flexibility and support to anyone who is struggling with any aspect of working from home.

Senior leaders need to be role models for the behaviors they expect from others and businesses focus more on equipping managers with the people management skills they need to manage and support homeworkers and remote workers. Employers also need to do more to provide more flexible work opportunities to people whose jobs make them unable to work from home through the use of better practices such as flexible time, job sharing, and busy and annual hours. “– Ben Willmott, Head of Public Policy, CIPD, the professional body for HR and human resource development

The CIPD recommends four areas of focus for UK organizations and human resources professionals:

  1. Supporting hybrid workers through sound human resource management: Design work processes to suit all locations, concentrating primarily on knowledge sharing, work coordination and team relations to drive performance and innovation.
  2. Ensure fairness of opportunity: Provides ongoing access to development and career conversations for all employees
  3. Prioritizing health and well-being: Ensures that employees are not overworked and reminds them of the importance of taking care of their physical and mental health and taking regular breaks, fresh air, and exercising.
  4. Offer a wider variety of flexible work options: Go beyond working remotely and see an introduction to a wider range of flexible work options such as job sharing, compressed hours, flexible start times and end times. Encourage flexibility from the start by hiring flexibly and making the right to request Flexible Work 1 day right.

“Flexible working takes on a new meaning, with remote working suddenly feeling ‘normal’. Employees have been empowered to think about where and how they are most productive, while employers are tasked with ensuring the tools they provide to their organizations are fit for today’s purposes. The ability to successfully support remote operations and distributed teams is now indispensable for business resilience and innovation, with technology playing a critical role. “Howard Lewis, Chairman of the Surface Business Group, Microsoft UK

Click here to download the full report.

1 The total sample size of YouGov’s study was 4282 employees surveyed who worked in offices, of which 2,863 worked in offices and worked from home. Unless otherwise stated, the findings in the report relate to a sample of 2,863 who worked in offices and worked from home.

See the source version at businesswire.com:https://www.businesswire.com/news/home/20210218005065/en/

CALL: Rebecca White

[email protected]

KEY WORDS: EUROPEAN KINGDOM UNITED STATES

INDUSTRY KEYWORDS: PROFESSIONAL SERVICES HUMAN RESOURCES TECHNOLOGY NETWORK CONSULTATION SOFTWARE

SOURCE: Microsoft English

Business Wire Copyright 2021.

PUB: 02/18/2021 03:00 AM / DISC: 02/18/2021 03:00 AM

http://www.businesswire.com/news/home/20210218005065/en

Business Wire Copyright 2021.

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