The governments of France, Germany, Italy, Great Britain and the United States welcomed the Libyan Political Dialogue Forum (LPDF) vote in favor of a new interim executive authority election mechanism, which will guide Libya to national elections on December 24. , 2021. This is an important step towards the unity of Libya. The LPDF decision affirms the clear demands of the Libyan people that it is time for a change in the status quo. We urge all Libyan parties to act promptly and in good faith to complete adoption through the LPDF of a united and inclusive government. As participants in the Berlin Conference process and international partner Libya, we will give our full support to the LPDF’s efforts.
We also welcome the appointment of the UN Secretary General Ján Kubiš as the Secretary General’s Special Envoy for Libya, and the appointment of Raisedon Zenenga as UNSMIL Coordinator and Georgette Gagnon as Resident Coordinator and Humanitarian Coordinator, and we will fully support them in their important role. We express our continued thanks to Acting UN Special Representative, Stephanie Williams, for her unwavering leadership in UN mediation until Mr Kubiš took up his position.
One year after the Berlin Conference, we underlined the important role of the international community in supporting a political solution in Libya as well as our ongoing partnerships with members of the Berlin Process. We remind members of the Berlin Process of the solemn commitment we all made at the summit one year ago, strengthened by UNSCR 2510. In particular, we must continue to support the ceasefire, restore full respect to the UN arms embargo, and end foreign poisoning. interference that undermines the aspirations of all Libyans to re-establish their sovereignty and choose their future peacefully through national elections. It is imperative that all Libyan and international actors support steps towards the full implementation of the Libyan ceasefire agreement signed on 23 October last year, including the immediate opening of coastal roads and the removal of all foreign fighters and mercenaries.
Despite decades of research, and its impact on one in 500 New Zealanders and millions more worldwide, Parkinson’s disease remains a medical mystery. Photo / 123RF
Kiwi scientists are trying to get closer to revealing the important role one gene plays in the development of Parkinson’s disease.
A new study comes after research in New Zealand, supported by the charity of world-renowned Hollywood star Michael J Fox, sheds light on the fascinating link of the gene to the notorious neurodegenerative condition.
Parkinson’s is a progressive neurodegenerative condition caused by a lack of dopamine in the brain, resulting in slow and awkward movements.
Despite decades of research, and its impact on one in 500 New Zealanders and millions more worldwide, the disease remains a medical mystery.
Doctors don’t yet know why most people develop it and for those who are diagnosed, there is no cure.
Over the past few years, scientists have been pursuing promising new clues in the genetic mutation that is one of the biggest risk factors for the disease.
The specific gene involved is called acid beta glucoserebrosidase, or GBA.
Research has shown how GBA mutations inhibit enzymes that help clear out damaged or excess parts of cells, before they can build up to cause the damage seen in Parkinson’s disease.
Last August, a team led by Associate Professor Justin O’Sullivan, from the University of Auckland-based Liggins Institute, published findings that pinpoint the specific components of GBA that play a major role in regulating and delaying the onset of disease.
In the “non-coding” area of GBA – once thought of as aimless “junk” DNA – the team screened 128 sites to find that, where the gene happened to have a specific combination of three short non-coding DNA sequences, Parkinson’s onset could be delayed by five. year.
They also identified six other non-coding regions that act as switches to control how the GBA gene is turned on or off in the brain’s movement and cognitive centers.
Scientists – funded in part by the Michael J Fox Foundation for Parkinson’s Research – are also creating maps showing how such switches affect other genes – apart from GBA – throughout the human body.
In the new study, supported by New Zealand’s Marsden Fund, O’Sullivan will work with University of Otago geneticist Professor Martin Kennedy to further explore the GBA puzzle.
Kennedy said the project proved to be an “accidental amalgamation” of initially separate research.
While O’Sullivan has focused on how gene expression is regulated in different cells, Kennedy and PhD student Oscar Graham has developed a new DNA sequencing method to check for mutations in the GBA gene.
When O’Sullivan and Kennedy sat together at the Queenstown conference to share their work, they realized what they could learn by putting it together.
“When put together, the two data sets show that not only clear mutations in GBA, but also a natural pattern of subtle variations in GBA genes, appear to impact Parkinson’s disease,” said Kennedy.
In addition, this may occur through changing the expression of perhaps 20 to 30 other genes.
Their joint study, which also involved the NZ Brain Research Institute’s renowned clinical director, Professor Tim Anderson, ultimately sought to confirm that subtle genetic changes in GBA do affect Parkinson’s early age.
But they also wanted to know why so many people who carry the GBA mutation don’t develop the disease.
Furthermore, they aim to build simpler ways of detecting variation so that it can be tested in larger studies, along with sophisticated new models exploring its effects in cell biology.
The team plans to import specific stem cells taken from Parkinson’s patients, which will be modified in the laboratory using the latest gene editing methods to provide cells with various forms of the GBA gene.
“These cells can be differentiated in the laboratory into different cell types, such as certain brain cells, then we can see differences in gene expression due to the presence of different forms of the GBA gene,” explains Kennedy.
“Then we’ll set up experiments to better understand the biological impact of differences in expression of any gene, both in cultured cell models, and ultimately in humans.”
Kennedy expects this pioneering research to come up with challenges – particularly around modifying genes in cell lines, but also in understanding what the differences in gene expression caused by different forms of GBA actually mean.
“Until we discover those changes and start thinking about gene function, we won’t be able to plan proper experiments to answer the key questions of this research.”
But if successful, their research may prove important for ongoing efforts to understand and prevent Parkinson’s.
“GBA is the single biggest genetic factor we know of that underlies Parkinson’s, but we don’t really understand how it exerts its effects,” said Kennedy.
“In addition, drugs are being developed and piloted that target the GBA and its lines of operation, so it is increasingly important to understand all the how and why of the GBA.
“We believe our genetic work will lead to a better ability to predict Parkinson’s risk – and possibly allow targeting of treatment, or even prevention for people at high genetic risk who don’t already have it.”
Bilawal highlights important but less ‘flashy’ projects
Web table – Posted: Jan 5, 2021 | Last Updated: 1 hour ago
Posted: Jan 5, 2021 | Last Updated: 1 hour ago
Sindh CM Murad Ali Shah and PPP Chairman Bilawal Bhutto Zardari discussed construction efforts at the inauguration ceremony for the Fishermen’s Field in Korangi Karachi on Tuesday. They highlight projects that are important but not too “flashy”.
CM Shah shared updates on various projects, saying that the funds needed to complete 25% of the Jalan Raya Malir project this year had already been spent. The remaining funds will be disbursed with the aim of completing the project next year, he added.
The chief minister spoke about an extensive environmental restoration program in Ibrahim Hyderi Korangi to Lat Pasti, which has suffered damage over the years as a municipal waste dump. The World Bank is funding the Yellow Line Project linking Korangi to Mazar-e-Quaid and work on the project is expected to start soon, he said.
CM Shah said encroachment was a major obstacle in efforts to improve the city’s water and sewer infrastructure. While the Sindh government is being blamed for not cleaning up encroachment, this role does not rest with the province, he said. The work falls under the domain of local government, particularly the Karachi Metropolitan Corporation, which he says allows this encroachment to emerge and affect the sewage system.
Bilawal said upgrading Karachi’s infrastructure was always a priority
Karachi people have long accused the federal, provincial and local governments of failing to provide much-needed roads, water supplies and sewage facilities. Politicians have been accused of neglecting these projects because of their poor optical value and focusing instead on successful projects for election campaigns.
Bilawal realizes the difficulties faced by the townspeople. He spoke about his party’s concern about Karachi’s development. “We have shared many studies with previous governments, including some that were funded and conducted by the World Bank,” he said. “But we get the same response every time: no funding.” He said the PPP had sought to resolve this problem by focusing on revenue collection and public-private partnerships. “We are the province with the best performance in terms of revenue collection,” said the head of PPP.
Bilawal spoke about the Sindh Government’s Environmental Development Program, which he says is funded by the World Bank. It focuses on improving roads, water supplies and sewerage infrastructure. He said the newly inaugurated Fishermen’s Field was the first delivery of the Sindh government’s vision. The head of PPP said that building safe and clean public spaces does not have to be “classy”, but is a building block for a healthy urban life. Safeguarding these spaces and keeping them safe from damage once inaugurated is important for the government, he added.
He said the next phase of their Environmental Development Program would include an upgraded water supply line and rainwater channel from Korangi to Ibrahim Hyderi.
On the issue of the census, he said, “Gerrymandering has been used to deprive Karachi citizens of their rights”.
“But Rome was not built in a day,” said the PPP chairman. “It takes time to fulfill promises, but the PPP is working tirelessly, day after day, to provide Karachi with the infrastructure it has long denied.”
Karachi, Sindh, Murad Ali Shah, Bilawal Bhutto Zardari, PPP, construction, projects, highways, roads, water, sewers
Prime Minister Imran Khan on Saturday said it was unprecedented how opposition parties had attacked the armed forces of these countries and had used the same language that India’s propaganda machine uses against Pakistan’s armed forces.
“The way the Pakistani political opposition is attacking the Pakistani Army, this is unprecedented in our history.
The prime minister addressed a meeting in Chakwal after laying the foundation stones of projects in the district. The project includes a university for the district, a 500-bed hospital, a ring road and a school. The project is estimated to cost around Rs15 billion.
Refer to the latest report based in Brussels EU Disinfolab With regard to India’s massive disinformation campaign against Pakistan using fake news websites and NGOs, the prime minister said the aim of the campaign was to present a negative image of the country.
“The aim is to present Pakistan with a negative outlook in front of the world and to illustrate that there is chaos so that no investment is coming into the country.”
He added that the Pakistani Army was also targeted in a campaign by India, with the aim of portraying it as a “rogue army or terrorist”.
The prime minister said fake news sites were also promoting the Pakistan Democratic Movement (PDM). “This is the first time in Pakistan’s history that the opposition has targeted the Army in this way. There have been no previous examples of this.”
Imran dismissed opposition claims that the establishment of the state played a role in cheating in previous elections. He asked the opposition if they had approached the court or the Election Commission of Pakistan (ECP). “Will you go to Parliament and discuss this issue?”
Criticizing the opposition, Imran said the country knew that opposition party leaders plundered the country for the past 30 years.
He also referred to articles and news in foreign publications detailing the parties’ corruption. Maintaining that the opposition attacks state institutions to protect their ill-earned wealth, he said that there has never been an “extremist, totalitarian, racist and anti-Muslim” political party in power in India.
“This is when we need them [Army] more than ever. I have never seen the opposition try to undermine a country like this just to get an NRO. “He added that India is also involved in terrorism in Balochistan.
“If any government gives them an NRO it will be the worst thing anyone can do to Pakistan.”
The prime minister went on and said that democracy holds its leaders accountable and said people should ask Bilawal Bhutto Zardari and Maryam Nawaz what their qualifications are to lead their political party. “If someone asked them what their work experience was they would say their father was the most corrupt person in Pakistan. This is their qualification. They haven’t worked an hour in their life and are here to run the country.”
Referring to the projects on which it is based, the prime minister said the universities and schools would produce talented young people from the region and give Chakwal people the opportunity to improve their prospects through education.
Imran promised to continue to support the project and invite the community to take advantage of this opportunity.
Earlier, Information and Broadcasting Minister Shibli Faraz compared PDM to ‘Indian Chronicles’ – a report released by EU DisinfoLab.
“On the one hand the external enemy is committing the crime of spreading false information against Pakistan through the Indian Chronicles and on the other the PDM is spreading frustration among the people by committing lies,” he said.
According to an investigation by EU Disinfolab, a coordinated influence operation, to malign Pakistan’s reputation, has been led by the New Delhi-based Srivastava Group and strengthened by Asia News International (ANI), an Indian news agency, for the past 15 years.
The mission of this operation is to discredit countries in conflict with India in the region, particularly Pakistan as well as China to some extent. In the long term, the campaign aims to strengthen India’s global perceptions, which will ultimately allow New Delhi to gain more support from international agencies such as the EU and the United Nations.