Tag Archives: fever

Possible inverse relationship between World Dengue Fever and COVID-19 in Brazil | Instant News

Researchers from Duke University, Federal University of Paraiba, University of Sao Paulo and the Oswaldo Cruz Foundation have looked at the link between the COVID-19 pandemic in Brazil and other factors, including the incidence of dengue fever in the region. Their study, entitled, “How cities with super-spread, highways, availability of hospital beds, and dengue fever affect the COVID-19 epidemic in Brazil,” released a pre-peer review on preprint. medRxiv* earlier this week.

What is this study about?

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 has gripped the world in a deadly pandemic that began late last year and, to date, has infected more than 32 million people. Brazil is third in the total number of COVID-19 cases. in more than 4.6 million. The first cases reported in the country on February 26, 2020.

Since the pandemic declaration in March 2020, international airports have been closed in the country to prevent the entry of infected people and the spread of the disease. Despite this, the geographic spread of infection was uneven across the country, write the investigators. The causes behind this uneven distribution of cases and the death rate in different parts of the country are unknown.

The researchers wrote, “… the route taken by SARS-CoV-2 to reach the rest of Brazil remains mysterious today.” The country has five official regions, “North (NO), Northeast (NE), Mid-West (CO), Southeast (SE) and South (S)”. Cases and deaths were unevenly distributed across the region, they wrote. There are differences in the incidence of new cases, the rate of growth or spread, the date of arrival of new cases from abroad, and the death rate. This was studied during the first six months of the pandemic in Brazil in this study.

Maps of Brazil are used to represent longitudinal (AD), transverse (EH), diagonal (IL), radial (MP), and connector (QT) major highway routes, as well as geographic evolution. distribution of COVID-19 cases on three dates (1 April, 1 June and 1 August), and distribution of COVID-19 deaths on 1 August (D). Overall, a cluster of 26 highways (see text) across all five road categories accounts for about 30% of the COVID-19 cases that are spreading across Brazil. The number of these multiple highways is highlighted in red. Note how many hotspots (in red) for COVID-19 cases occurred in micro-regions containing cities located along major highway routes such as BRs 101, 116, 222, 232, 236, 272, 364, 374, 381, 010, 050, 060, 450, and 465. Although the spread of COVID-19 cases and deaths are correlated, the geographical differences between the two distributions can be seen clearly by comparing them on August 1 (C and D). The color coding (See Figure below) ranks Brazil’s micro-regions (each consisting of multiple cranes) according to the number of COVID-19 cases and deaths.

What was found?

The results of this study indicate that there are four significant factors associated with the uneven spread of COVID-19 cases in Brazil. This is found using mathematical modeling. Some of the highlights of these findings are;

  • The super-spreading areas include the city of São Paulo where there are 80 percent of all cases in the country
  • 16 cities accounted for 98 to 99 percent of all cases in the first 3 months of the pandemic.
  • The 26 major highways are responsible for 30 percent of the spread of COVID-19 cases
  • Cases are increasing in rural areas. However, due to the lack of intensive care unit (ICU) beds in rural areas, the seriously ill cases had to be moved to the cities where they died of infection. This led to a mortality rate in sloping cities, write the researchers. They call it the “boomerang effect.”
  • There were 3.5 million cases of dengue fever between January 2019 and July 2020. Areas with high antibody (IgM) levels for dengue fever have a lower incidence of COVID-19, as well as lower rates of infection growth and mortality. .
  • The negative relationship between COVID-19 is not seen with IgM data for the Chikungunya virus
  • The team wrote, “Although there are more cases of dengue fever in the NE, compared to the NO region, the region is dominated by cities with high COVID-19 and a low incidence of dengue … More cities with a high incidence of dengue fever, and a very low incidence of COVID-19, occurring in the SE and SO regions. “There is a very low incidence of cases in Paraná, Santa Catarina, Rio Grande do Sul, Mato Grosso do Sul after the initial surge in March 2020.

(A) Individual contributions from 17 state capitals responsible for 98% of the spread of COVID-19 cases for 5,570 cities in Brazil, from March 1 to June 11. Note how São Paulo contributed to more than 80% of all cases that spread during the first weeks of March. During the period until 11 June, São Paulo’s contribution never fell below 30%. For this reason, the city is labeled as the city that spreads COVID-19 in Brazil. Note also the high contributions of Rio de Janeiro, Brasilia, and the five state capitals of the Northeast: Fortaleza, Recife, Salvador, São Luís, and João Pessoa. Manaus and Belém are the largest distribution cities in the Northern region (Amazon) and Porto Alegre and Curitiba the most important in the South. During this period, the contribution of Goiânia, Campo Grande and Cuibá, to the Central-West region was the largest in their region but much smaller in comparison to other regions and their distribution. (B) Bar indicates the day the first COVID-19 case (blue bar) was officially reported in each state (using São Paulo’s first case on 26 February 2020 as a reference 0), the number of days estimated by the mathematical model for each state is 500 cases per 100,000 population (yellow bars), and the days each Brazilian state actually hit the 500 cases per 100,000 population mark (orange bars). Note how long it takes states such as MT, BA, SC, SP, GO, MS, PR, MG to reach the 500 / 100,000 mark when compared to states such as AP, AM, RR, AC, PA, and TO in the Region north, MA, CE, PB, PI, SE, AL, and RN in the Northeast region, ES in the Southeast region, and DF in the Mid-West region.

Implications of the findings

The team wrote, “This inverse correlation between COVID-19 and dengue fever was further observed in a sample of countries in Asia and Latin America, as well as on islands in the Pacific and Indian Ocean.” They note that there is a possibility of “immunological cross-reactivity” between DENV serotypes (dengue antibody) and SARS-CoV-2, dengue infection or immunization with the dengue vaccine can protect against SARS-CoV-2 so that it is safe and effective against SARS-CoV- 2 is available.

Professor Miguel Nicolelis, lead author of the study from Duke University, said in a statement that viruses could have cross-reactivity that could be explored. This is an unexpected finding from this study, he said.

The researchers speculate that there are other flaviviruses such as Zika and yellow fever that may have cross immunological interactions with SARS-CoV-2, which need to be explored. This can provide a solution to stop the growth rate of the infection. They especially hope the yellow fever vaccine can help prevent the spread of SARS-CoV-2 if it shows cross-immunoreactivity. This speculation, however, will require clinical studies to prove effective until a safe and effective vaccine against the virus becomes available.

* Important Notice

medRxiv publishes preliminary scientific reports that are not peer reviewed and, therefore, should not be construed as conclusions, guidelines for health-related clinical / behavioral practice, or are treated as defined information.


image source

Made more-ratings fever as a symptom affects the initial Covid-19 the answer? Yes, says study OIMN | Instant News

Police received a sample of a nasal swab taken for Covid-19 test at the government fever hospital in Hyderabad on July 23, 2020. (AP photo/Mahesh Kumar A.)

A study conducted by the gateway of India shows that in the early days of the pandemic in March-April, only 17% of patients fever.

  • CNN-News18 New Delhi
  • Last Update: July 25, 2020, 1:04 PM ist

We missed Covid-19 patients in the first days of the pandemic? Possible. A study conducted by all India Institute of medical Sciences (AIIMS) now shows that fever was never a predominant symptom of the disease caused by a coronavirus.

A study published in the scientific research arm ICMR, Indian journal of medical research (IJMR), shows that in the early days of the pandemic in March-April, only 17% of patients fever.

Research on 144 patients was conducted from 23 March to 15 April in new Delhi-Qutab Minar. Research paper topic ‘clinical and demographic profile and in-hospital outcomes of Covid-19 patients hospitalized in a center of tertiary care in Northern India, was in collaboration with the Director, Dr Randeep Guleria from 28 others.

“The fever is present in only 17% of our patients, which was much less compared to other reports worldwide, including Chinese cohort, which is 44%, the temperature at the time of presentation and 88% had fever during the stay in the hospital,” the research work is carried out News18 said.

He continues to add that 44% of patients were asymptomatic at the time of admission. A large number of asymptomatic patients of both good and bad news. While on the one hand it shows that many patients develop an immunity to the infection, it also shows that in March-April, was a silent spreaders.

Both public and commercial institutions, including airports, hospitals, shopping centers, relied heavily on thermal body scan and manual thermometers to regulate the movement of people in the early days of the pandemic, questioning the effectiveness of the transition, when the fever is not the dominant symptom.

The aim of the study was to describe clinical and demographic characteristics and in hospital outcomes Covid groups-19 patients in North India.

The average age of the 144 patients was about 40 years old, with 93.1% of men and included 10 foreigners. Domestic travel to or from affected countries (77.1%) and close contact with Covid-19 patients in the community (82.6%) are the most commonly documented exposure.

Nine patients were smokers, while comorbidities were present in 23 patients, of which diabetes was the most common health.

A significant proportion (about 44%) patients had no symptoms. Those who had the symptoms complained of cough as the most common symptom, while fever was the most unusual. Nasal symptoms were present in 2% of patients. The majority of patients is maintenance treatment with hydroxychloroquine and Azithromycin is given in each case. Requires only five patients, oxygen, four required intensive care, and one required mechanical ventilation and mortality occurred in two patients. Patients recovered in 16-18 days, said the study.

Speaking to News18, Dr Randeep Guleria said that every day is a learning process and that there needs to be a wider lens to study the symptoms Covid-19. Infection is much more systematic than what was earlier believed, he said.

“We had young people with strokes and they were Covid-19 patients. We have had patients with a heart attack, which was Covid-19 patients. I had a patient who came to me with diarrhea, no respiratory symptoms, and he thought that due to blocking drinking water he consumed was not fresh, which leads to diarrhea. He has no respiratory symptoms. He continues to have diarrhea for five to seven days. We see Covid-19 patients with conjunctivitis, the eye damage. These extrapulmonary manifestations and we should have a high index of suspicion and low threshold for testing as we go along”, he added.


image source

Tests the collector of Coimbatore positive for coronavirus, admitted to a private hospital | Instant News

The test result was positive on Wednesday morning, and he was mostly asymptomatic.

Coimbatore district collector K Rajamani has tested positive for coronavirus on Wednesday morning and was admitted to a private hospital for treatment.

The collector temperature rose Monday morning, and so he gave her swabs to test on Tuesday. After that, his test result was positive on Wednesday. The collector was placed in the medical center Kovai and hospital (kmch).

Clerk of the district health TNM confirmed that the collector is positive for coronavirus.

Official district medical Ramadurai Murugan said, “the collector visited the area of deterrence, to help planning, monitoring spread of the virus. He got a slight fever over the last few days and as it was in the cases of the coronavirus, he yesterday gave the test. It was positive this morning and admitted in a private hospital. It is largely asymptomatic until now”.

The collector was actively involved in the activities of the district administration to stop the proliferation of COVID-19. Collector conducts a sudden inspection of the protection zones within the district.

July 2, collector visited Selvapuram and Telugu street germasino and communicate with people. According reports34 people tested positive in the area of deterrence Selvapuram. Cluster Selvapuram out of gold prefabrication.

As of Tuesday night, Coimbatore was 188 new cases of coronavirus. Currently, the district has 1131 active cases of coronavirus. In Coimbatore, 1,480 people tested positive for coronavirus, of which 338 persons were discharged after recovery. The district reported one death from the outbreak of coronavirus.

In Tamil Nadu, 1,47,324 people have tested positive for the coronavirus so far. While the state performs more than 97 000 people, the state 47,912 active cases COVID-19.


image source

New AI Diagnostic Tool Can Predict COVID-19 Even Without Testing | Instant News

The diagnosis of artificial intelligence (AI) can be used to predict if a person is likely to develop COVID-19, based on symptoms, according to a recent study by researchers at King’s College London, Massachusetts General Hospital and health science company ZOE.

The AI ​​model uses information from the coronavirus symptom study application to predict COVID-19 by comparing the symptoms exhibited by people with the results of traditional testing methods. This method can be very helpful in countries where access to testing is limited. Several clinical trials in the US and UK will begin soon.

More than 3.3 million people worldwide have downloaded the application and have used it to report their health status every day – whether they feel healthy or if they have experienced all the new symptoms including coughing, fever, fatigue, and loss of smell or taste.


The research team analyzed information collected from about 2.5 million people living in the US and the US who regularly record their health status in the app. About one third of them have noted symptoms related to COVID-19. More than 18,000 people reported that they had undergone coronavirus testing and around 7,178 of them tested positive for COVID-19.

The researchers investigated which COVID-19 symptoms were most likely to be associated with positive test results.

Key findings from this study:

  • Only fever and cough are warning signs of coronavirus
  • Loss of taste and odor is a stronger predictor of COVID-19 than fever
  • Four main symptoms of COVID-19: loss of smell or taste, severe or persistent cough, fatigue and skipping meals
  • Only one fifth of those who are unhealthy tend to have COVID-19
  • Combining this prediction of AI with broad application adoption can be used to identify those who are likely to contract the infection as soon as the earliest symptoms begin to appear.

“Our results indicate that loss of taste or odor is a key early warning sign of COVID-19 infection and should be included in routine screening for this disease. We strongly urge governments and health authorities everywhere to make this information more widely known, and advise who even those who suddenly lose their smell or taste to assume that they are infected and follow local self-isolation guidelines, “MedicalXpress quoted professor Tim Spector from King’s College London.

coronavirus home testing kit Photo: geralt – pixabay


image source

California will Reveal Guidelines that Allow Some Businesses to Reopen – NBC Los Angeles | Instant News

Business owners across California are anxiously awaiting Thursday’s new guidelines from Governor Gavin Newsom, which will outline broad changes to home stay orders across the state that close most retail stores to slow the spread of the corona virus.

Newsom is expected to allow businesses such as clothing stores, flower shops, bookstores and sporting goods stores to open their doors for the first time in almost two months, with some restrictions. The governor said the order would not cover other close contact businesses, such as eating in restaurants and hair salons. However, he also said some local governments could accept variants.

Guidelines for Reopening the White House Leave Room for Interpretation

For countries considering raising quarantine measures, official guidelines recommend a COVID-19 trajectory down in two weeks or a downward trajectory of a positive test as a percentage of the total test.

As shown below, when you compare the number of new cases yesterday with those from two weeks ago, the numbers are often lower, simply because the numbers fluctuate. Criteria has been criticized by some for being unclear, creating opportunities for any governor to argue that the numbers are good enough to start reopening.

Since home stay orders were issued on March 19, more than 4 million people have been removed from work in the most populous state.

The guidelines are part of Newsom’s four-step plan to reopen the country. Thursday will be phase two. The next phase, which can reopen salons, gymnasiums, cinemas and private church services, can be in a few months. Phase four will end all barriers and allow large meetings at concerts and sporting events.

The Newsom administration is tracking six indicators to determine when to reduce restrictions. They include the ability of the state to test people for COVID-19 and track who might be exposed to it and the capacity of hospitals to deal with potential spikes in new cases.

So far, Newsom said the country was on track to fulfill its objectives.

How Long Until Coronavirus Will Cause Use Of Top Hospitals Across The Country

This interactive chart uses the data model provided by Institute of Health Metrics and Evaluation to predict how coronavirus will affect health care resources in various countries. The maximum use of hospital beds in some states, such as New York, has passed while in others stay a few more weeks. Most states have enough public hospitals and ICU beds to meet demand, according to additional data from The Associated Press.

Newsom’s orders have been universally accepted today.

But three northern California states with few confirmed COVID-19 cases have allowed businesses to reopen. Tiny Modoc County allowed the only cinema to open its doors. Yuba and Sutter districts allowed in-store shopping and restarted fitness centers and fitness studios, salons, spas and tattoo rooms, libraries and playgrounds.

General Manager of Yuba Sutter Mall Natasha Shelton said about 18 of about 50 stores were open Wednesday and an estimated 200 people were inside during the day. Mall has reduced hours to allow for additional overnight cleaning. Tables in the food court are 6 feet apart and food trays are prohibited.

Newsom has cracked down on rogue counties before, ordering the temporary closure of all beaches in Orange County after several local governments refused to close it or impose public health restrictions. He lifted several orders after negotiating with the local government.

In Los Angeles, regional official outlining a plan that allows some reopening starting Friday, provided safety precautions are taken. Golfers can find the link again, and the trail will open with regional employees ready to remind pedestrians of the rules of social distance, said Chair of the Board of Trustees Kathryn Barger.

Some retailers in Los Angeles County can reopen with only roadside pickups – including florists and stores that sell toys, books, clothing, sporting goods and music. The district, the largest state with 10 million inhabitants, has caused more than half more than 2,500 deaths from the California virus.

California is no. 1 destination for travelers in the United States and coronavirus has ill status. Angie Crouch reports on NBC4 News at 5 pm on Wednesday, May 6, 2020.

For most people, new coronaviruses cause mild or moderate symptoms, such as fever and cough that go away in two to three weeks. For some people, especially older adults and people with existing health problems, can cause more severe illnesses, including pneumonia and death.


image source