Tag Archives: Genetics

CRISPR gene editing can be used to treat cancer-BGR | Instant News

  • Scientists have developed a new system that uses the CRISPR genome editing system to attack and kill cancer cells.
  • The goal of this system is to eliminate cells directly, just like “scissors”, cutting their DNA and killing them.
  • Additional trials and tests are needed, but promising new systems can eventually be used to fight cancer in humans.

Since human doctors realized that this is fatal, the fight against cancer has been ongoing. Although it always seems to be out of reach with real treatments, many advances have been made in the fight against the disease. Researchers at Tel Aviv University believe that with the help of the CRISPR genome editing system, they are moving towards this incredible goal.

As the scientist published in Scientific progress, The tool was developed to correct potentially harmful genetic quirks, and may prove to be the ultimate tool to eradicate deadly cancer. The team’s research shows that by using what they call a “new lipid nanoparticle-based delivery system,” they can specifically target cancer cells and effectively kill them without the opportunity to reactivate them.

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The description of how this system attacks cancer cells sounds absolutely incredible. Scientists use nanoparticles to send messages to the CRISPR enzyme Cas9 to target cancer cells and “act as molecular scissors” to slice the cell’s DNA and kill it.

Researchers are trying to prove that the system can work by targeting glioblastoma and metastatic ovarian cancer, the two cancers with the highest mortality rates. As we all know, they are aggressive cancers that kill many people every year. When targeting these cancers in mice, a single treatment with the new CRISPR system can double the animal’s survival rate. It was after just one round of treatment, which is very incredible.

Professor Dan Peer, the co-author of the study, said: “This is the first study in the world to prove that the CRISPR genome editing system can be used to effectively treat cancer in living animals.” Said in the statement. “It must be emphasized that this is not chemotherapy. There are no side effects, and cancer cells treated with this method will never be active again. Cas9 molecular scissors cut the cancer cell’s DNA, thereby neutralizing and permanently preventing replication.”

Looking to the future, researchers hope to try to solve other kinds of diseases, including blood cancer and genetic diseases, to understand how much the gene editing system can make. If the test proves to be promising, we may soon see that CRISPR can be used for a variety of diseases, and even as a promising tool to eliminate many types of cancer.

Mike Wehner has covered technology and video games over the past decade, covering major news and trends in VR, wearables, smartphones and future technologies. Recently, Mike served as the technical editor of The Daily Dot, and has gained attention in USA Today, Time.com, and countless other online and print shops. His love of reporting is second only to his addiction to games.


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Breakthrough therapy is proven to shorten the time of human aging – BGR | Instant News

  • Scientists have developed a new therapy that they say can actually reverse aging at the genetic level.
  • By letting participants breathe pure oxygen in a hyperbaric chamber for five months a week for three months, the team can effectively reverse the age of chromosomal telomeres.
  • Obviously, other research is needed in this area, but so far, the results are promising.

Life as we know it follows an inevitable path that we call aging. Due to the nature of our DNA, humans have a limited lifespan (in terms of animal life on earth, it is actually all DNA). But by determining the way our DNA changes with age, and reversing the damage it causes over time, Israeli researchers seem to have taken a small step towards establishing a science-based fountain of youth step.

Such as telegraph According to reports, the team of scientists at Tel Aviv University focused on a part of chromosomes called telomeres. The telomeres at the ends of our chromosomes are longer when we are born, and become shorter over time. They are the protective features of our genes. As we age, they shorten, DNA damage will occur, and as a result our bodies begin to collapse.

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Therefore, researchers have proposed a novel treatment method to solve the problem of aging. They want to see if oxygen can reverse and restore DNA vitality, effectively shortening time by extending telomeres and enhancing their defense capabilities.

In the three-month trial, volunteers age 64 and older sat in a hyperbaric chamber and were asked to wear a mask to breathe. The mask provided 100% oxygen, and each participant sat indoors for 90 minutes five days a week. After the trial period ended, the researchers checked the participants’ DNA and found that the individual’s telomeres were “young” again. Scientists say that telomeres look like the participants in their 20s, which is indeed a remarkable achievement.

In addition, oxygen therapy can be used in combination with other types of anti-aging therapies to further increase the life span of animals including humans. There has not been any detailed research on the end results of using multiple therapies. Although the DNA of study participants does show specific benefits on a microscopic level, it is still unclear how these changes translate in terms of lifespan. Will these participants live longer? If so, how long will it take? Are there potential drawbacks to this therapy?

These and other questions need to be answered before anyone can claim that they have found a way to extend human life beyond what can be achieved by a healthy lifestyle alone.

Mike Wehner has covered technology and video games over the past decade, covering major news and trends in VR, wearables, smartphones and future technologies. Recently, Mike served as the technical editor of The Daily Dot, and has gained attention in USA Today, Time.com, and countless other online and print shops. His love of reporting is second only to his addiction to games.


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How the flu virus spreads in cities | Instant News

PICTURE: Flu virus
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Credit: CDC, 2020

New insights on the local transmission of seasonal influenza may be valuable for planning interventions to combat the spread of respiratory disease within cities, according to a study published November 19, 2020 in the open access journal. Pathogenic PLOS by Nicola Müller and Tanja Stadler of ETH Zurich, and colleagues.

As demonstrated by the current severe acute respiratory syndrome pandemic coronavirus 2 (SARS-CoV-2), respiratory disease can rapidly spread around the world. While it is important to understand how disease spreads globally, local spread is most often the main driver of new infections of respiratory diseases such as SARS-CoV-2 or influenza. In the absence of in-depth knowledge of the important drivers of the local spread of SARS-CoV-2, governments around the world have been forced to shut down communities to reduce the burden of the coronavirus disease (COVID-19). Similar to SARS-CoV-2, relatively little is known about the local spread of seasonal influenza, although it infects a large proportion of the global population annually.

In this new study, researchers answered this question by collecting influenza samples and demographic information from 663 patients at two hospitals and various private practices in Basel, Switzerland, during the 2016/2017 influenza season. The genetic sequencing of the influenza virus reveals that hundreds of city introductions drive influenza season. Some evidence suggests that transmission dynamics at Basel may be related to temperature. In addition, most of the elderly people are infected within their own transmission network. Within the remaining network of transmission, additional analyzes suggest that school-age children are likely to play a more central role in driving the local spread of influenza than do preschool children. According to the authors, these findings could lead to more efficient and efficient public health interventions to reduce the enormous social burden caused by seasonal flu.

The authors conclude, “By enabling us to see how each case is linked, the genetic sequences of influenza viruses isolated in Basel, Switzerland show us that influenza viruses repeatedly enter Basel from around the world in one season”


Research Articles

Peer reviewed; Observational study; People

Funding: The project is funded by the Swiss National Science Foundation (SNF; grant number CR32I3_166258), Freiwillige Akademische Gesellschaft Basel and the Swiss Red Cross. AE received additional grants for this project: Freiwillige Akademische Gesellschaft Basel (with TS), Blutspende Zentrum SRK, and partial salary from SNSF Ambizione (PZ00P3_154709 / 1). The donor has no role in study design, data collection and analysis, decision to publish, or manuscript preparation.

Competitive Interests: The authors have stated that there are no competing interests.

Quote: Müller NF, Wüthrich D, Goldman N, Sailer N, Saalfrank C, Brunner M, et al. (2020) Characterization of the epidemic spread of influenza A / H3N2 in a city through phylogenetics. PLoS Pathog 16 (11): e1008984. https: //doi.org /10.1371 /journal.ppat.1008984

Author Affiliations:

ETH Zürich, Department of Biosystems Science and Engineering, 4058 Basel, Switzerland

Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

Bacteriology and Clinical Mycology, Basel University Hospital, Basel, Switzerland

Biomedical Department, University of Basel, Basel, Switzerland

Human Geography, Department of Environmental Sciences, University of Basel, Basel, Switzerland

In your coverage, use this URL to provide access to a paper that is freely available: http: // journals.plos.org /plospatogen /article? id =10.1371 /journal.ppat.1008984

Rejection: AAAS and EurekAlert! is not responsible for the accuracy of news releases posted to EurekAlert! by contributing to or for the use of any information via the EurekAlert system.


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Using AI to unlock the genetic secrets of food | Instant News

One startup is using machine learning to identify what it calls “nutrient dark matter”.

Why is it important: More than 99% of phytonutrients – natural chemicals produced by plants – are unknown to science. If we can light up that dark matter, we can identify and grow compounds in food for specific health values.

How it works: Startup Brightseed uses a proprietary AI platform called Forager to predict the likelihood that plants have useful natural compounds and the likelihood that these phytonutrients may have certain health benefits.

  • These platforms are trained in large libraries of biomedical and plant research. That allows AI to make the connection between plant ingredients and health effects much faster than any human scientist can.
  • “It effectively works as a Google search engine for these compounds and what they can do,” said Jim Flatt, CEO of Brightseed. “Once we find the compound, we can develop products and services around it.”

Details: The Forager system can filter by specific chemical compounds, or based on health benefits, looking for materials which might affect cholesterol or cognitive function.

  • Earlier this year Brightseed announced a partnership with Danone North America to use the Forager system on soybeans.
  • That’s a sign that even one of the most widely used plants on Earth may have additional nutritional secrets that AI can uncover.

What they say: “AI allows us to deal with things that would have taken too long in the past computationally,” said Flatt.

Underline: As interesting as possible use biotechnology to synthesize an entirely new compound is, we are only just beginning to understand what is already in the world – and AI can accelerate that discovery.


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The Italian Island Mysteriously Freed from COVID-19 | Instant News

Who would have thought there was an island there Italy who escaped the deadly virus after recording more than 240,000 cases and 35,000 deaths? Maybe there isn’t any, even the knitted residents.

For example, Paola Muti, a cancer researcher at the University of Milan, is worried that the tiny Giglio Island will be hit hard by COVID-19 after reports of people infected with COVID-19. He prepared for the rapid spread of disease to the island with more than 800 inhabitants.

(Photo: Wikimedia Commons)
Sun Umbrellas on Giglio Island

His mother is a native of the island, born and raised there. He often lives in a family home with a beautiful view overlooking the sea through the living room window. To the surprise of its inhabitants, no one on the island experienced symptoms of COVID-19 even though the environment and conditions seemed favorable for diseases transmitted directly like fire.

Also Read: Air and Water Quality in Italy Improves Amid Worsening COVID-19

Giglio Island: Avoided COVID-19

Population Giglio Island, also known as Giliesi, is known to socialize in steep alleys near the harbor or in narrow streets in the hilltop Castle neighborhood, full of houses built against the remains of fortresses that were built centuries ago as protection against the pirate.

The sole doctor of Giglio Island for 40 years, Dr. Armando Schiaffano, shared Muti’s concerns about the possibility of a local outbreak. He said that every time someone was sick even from childhood illnesses as usual dengue fever, measles, or chicken pox, almost all residents will fall ill within a few days.

Muti is confused about how the small island of Giglio can avoid infection. He was trapped on the island after the country implemented national lockdown. Indeed, it is a mystery that although the residents continue to have close contact with visitors, none of them have fallen ill.

Their first known COVID-19 case was a 60-year-old man who arrived on February 18, a few days before Italy recorded its first indigenous case. The man came to Giglio for the funeral of a relative and was already experiencing symptoms. He returned to the mainland the same day and died three weeks later.

Then on March 5, three more visitors came from mainland Italy and tested positive. In addition, another islander who lived in Australia for two years returned to Giglio in mid-March and experienced a mild fever and was declared positive.

No other case has been recorded since then, and even when the lock has been removed June, and tourists arriving from Italy have arrived.

Also Read: Italy Approaches Herd Immunity as More Than Half of its Epicenter-Covid-19 Population is Tested Positive for Antibodies

Why did the island survive?

Health officials from Tuscany, where Giglio was part of it, carried out antibody tests on island residents. Out of 800 or more residents, 732 volunteered to be tested. They said that they all wanted to do it to be calm about possible infections and help science too.

Even Reverend Lorenzo Pasquotti, who performed a funeral attended by 50 people, volunteered for testing. He noted that during the ceremony, many people greeted each other and exchanged hugs and kisses.

Still curious that no one on the island was infected, Muti suspected that perhaps the island’s population was not sufficiently exposed to COVID-19 to become infected.

But some scientists argue that it might be because of the unique genetic makeup it has or it might be purely due to luck.

Read more: Italian Doctors Recognize Coronavirus Genetic Mutations May Be Weaker and Can Disappear Without Vaccines

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