Tag Archives: HYDROXYCHLOROQUINE

Coronavirus | Germany is threatening legal action over the vaccine delay | Instant News


Brussels implicitly accuses AstraZeneca of giving preferential treatment to Britain in its vaccine shipments, at the expense of the EU.

The German government on Sunday threatened to take legal action against laboratories that failed to deliver a coronavirus vaccine to the European Union as scheduled, amid tensions over delayed deliveries from AstraZeneca.

“If it turns out that companies are not respecting their obligations, we have to decide the legal consequences,” Economy Minister Peter Altmaier told German daily Die Welt.

“No company can support any other country than the EU after that fact,” he added.

There have been mounting tensions in recent weeks between European leaders and British-Swedish pharmaceutical giant AstraZeneca, which has missed its promise of delivering a COVID-19 vaccine.

The company said it can now deliver only a quarter of the originally promised dose to the block for the first quarter of this year due to problems at one of its European plants.

Brussels implicitly accuses AstraZeneca of giving preferential treatment to Britain in its vaccine shipments, at the expense of the EU.

The EU had threatened to limit vaccine exports to Northern Ireland by ruling out part of a Brexit deal with Britain that would allow the free flow of goods over the Irish border. It backed off after British Prime Minister Boris Johnson voiced “great concern”.

AstraZeneca is not the only drug company in the firing line.

Last week, Italy threatened legal action against US pharmaceutical company Pfizer over the delay in delivering a promised vaccine.

Top German officials will meet with drug manufacturers to discuss the issue of delay.

On Friday, the European Medicines Agency released a vaccine manufactured by AstraZeneca for use within the EU, the third Covid-19 vaccine approved after Pfizer-BioNTech and Moderna.

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Brazilian President Jair Bolsonaro urged the PM to “speed up” vaccine deliveries | Instant News


Under pressure from political rivals to respond to the pandemic, the Brazilian President called for the swift export of 2 million doses of Covishield.

Under considerable pressure to start the vaccine rollout, Brazilian President Jair Bolsonaro has written to Prime Minister Narendra Modi, asking the Indian government to “speed up” exports. two million doses of AstraZeneca vaccine, ‘Covidshield’, produced at the Serum Institute of India (SII) in Pune, is expected to be delivered next week.

“To [ensure] the immediate implementation of the Brazilian National Immunization Program, I would appreciate your kind services in accelerating the immediate delivery of the two million doses of the vaccine produced by the Serum Institute of India to Brazil, but as long as it does not impact India’s vaccination program, “Mr. Bolsonaro wrote to Mr Modi on Friday, according to the translated version of the letter accessed by Hindu.

Also read: The Oxford / AstraZeneca vaccine will be approved by the end of the year: Report

Government officials said replies had not been sent to Bolsonaro at this time. When contacted, the SII representative declined to comment on the Brazilian request.

With more than 8 million cases of COVID-19, Brazil is second only to the US (22.4 million cases) and India (10.4 million cases), but in terms of the number of deaths from the virus, Brazil with over 200,000 of these deaths week, is second only to the US (378,000+ deaths), and much higher than India’s 150,000+ deaths.

Also read: AstraZeneca says its vaccine must be effective against the new coronavirus variant

As a result, Bolsonaro, who has repeatedly been skeptical of COVID-19 – calling it ‘just the flu’ – and vaccines – showing they can have extreme side effects – has come under growing criticism for his government’s slow response to the pandemic. from political and media opponents in Brazil. In particular, Bolsonaro’s government has faced challenges from provincial governors and mayors in Brazil, including his main election rival, Sao Paolo Governor Joao Doria, who announced that he would start providing China Coronavac in his state on January 25.

Earlier this week, Bolsonaro took over his refusal of the Chinese vaccine, and his government announced that it had signed a contract for up to 100 million doses of Coronavac, which will be produced at Brazil’s Butantan Institute in the coming days. Sunday.

Brazil’s Oswaldo Cruz Foundation has contracted with AstraZeneca to produce 100 million doses, but this may not be ready until March. In addition, the Brazilian Association of Vaccine Clinics (ABCVAC) has signed a memorandum of understanding (MoU) with Bharat Biotech to personally purchase Covaxin, which is currently in the final stages of clinical trials, and has received conditional clearance from Indian drug regulators.

As a result, the Brazilian government is interested in getting ready-to-inject vaccines as soon as possible, and is awaiting ANVISA approval from its own drug regulator for them later this month.

The letter from the Brazilian president, who visited India as the main guest for Republic Day last year and is believed to have close ties to Modi, comes months after another letter he sent to the prime minister in April asking India to withdraw. the export ban on hydroxychloroquine (HCQ), is thought to help prevent and treat the corona virus.

Sources said the request was also triggered by concerns over the suggestion of SII CEO Adar Poonawalla in an interview on January 3 that the Indian government had restricted vaccine exports until domestic needs were met.

According to Itamaraty (Brazilian Ministry of Foreign Affairs), the Executive Secretary of the Brazilian Health Ministry met with the Indian Ambassador in Brasillia Suresh Reddy to “solve this problem” on January 4.

“The Brazilian Embassy in New Delhi, in turn, is in permanent contact with Indian authorities to emphasize the importance of initiating vaccinations in Brazil,” said a release from the Brazilian Foreign Ministry.

New Delhi later clarified that it had no plans to limit the supply of the coronavirus vaccine to other countries, and a joint press statement issued by SII and Bharat Biotech confirmed this on January 5.

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The victims of the Brazilian coronavirus reached 75,000 | Instant News


By Mauricio Savarese and David Biller | Associated Press

SAO PAULO – A thousand deaths a day.

Since the end of May, three months after the first coronavirus case reported in Brazil, has recorded an average of more than 1,000 deaths every day in the terrible highlands that have not been tilted down.
The country hit at least 75,000 deaths on Wednesday and is expected to report 2 million cases of COVID-19 on Thursday night.

Even as cases are reduced in the largest and most severe cities in Brazil, the virus is mounting in new locations throughout the largest countries in Latin America.

Experts blame President Jair Bolsonaro’s potential rejection of the virus and the lack of national coordination combined with scattershot responses by city and state governments, with some reopening earlier than recommended by health experts.

A temporary health minister who is not trained in the field leads the pandemic response. Bolsonaro himself was fed up with COVID-19 after repeatedly jeering at the recommendation of social distance and breaking the boundaries of local leaders in activity.

The death of Brazil around 7,000 COVID-19 in each of the last seven weeks is the same as several planes full of Brazilians that crash every day, former health minister Luiz Henrique Mandetta told The Associated Press.

“People become heartless,” Mandetta said. “When you say, ‘Yesterday there were 1,300 deaths,’ people said, ‘OK, then that didn’t go up. That’s 1,300 people the day before too. ‘”

Nearly 2 million cases in Brazil are second only to the United States and experts believe that the number is still below the count due to lack of testing. A model made by professors from several Brazilian academic institutions, based on the number of confirmed deaths, estimates that Brazil has had 10 million infections.

“The virus will be difficult to stop. But the milestone of these 2 million cases, which is highly underestimated, shows this could be different, “said Dr. Adriano Massuda, a health administration specialist and professor at Getulio Vargas Foundation, a university in Sao Paulo. “There is no national strategy for testing, no steps from the top, … too little effort to improve basic care so we find serious cases before they become too serious, no tracking.”

The virus has begun to reach cities and states that were previously spared, offsetting declines elsewhere. The number of deaths has receded in countries including Rio de Janeiro and Amazonas, where people are buried in mass graves in the capital, Manaus. In the past two weeks, 10 of the 26 Brazilian states and the Federal District have increased, with the average daily death toll in the two southern states doubling.

Bolsonaro has consistently underestimated the severity of COVID-19, said social measures that steer away from job and income sacrifices would ultimately be more dangerous than the virus itself, and called on supporters to encourage their local leaders to lift restrictions on activities. Many mayors and governors are struggling to defend it.

In Ribeirao Preto, a city in the state of Sao Paulo, protested shop owners on Wednesday demanding they be allowed to reopen. They surrounded the mayor’s car when he left City Hall, punched his window and cursed him.

Campinas, a city of 1.2 million people closer to the state capital, adopted quarantine measures earlier, but succumbed to political pressure and reopened trade on June 8, said Pedro de Siqueira, a member of the Campinas city council. The city center is filled with buyers like upside down ant nests, he said in an interview.

Two weeks later, the number of COVID-19 deaths tripled to 253, as did the number of confirmed cases, to 6,324. Intensive care beds were replenished with patients, prompting the mayor to reinstate trade restrictions on June 22, but allow offices and churches to continue operating.

“Campinas reopened prematurely and erroneously, supported by the state government,” said Siqueira, who is also a public health doctor, at the time. “This reopening was so powerful that Campinas had to step down, but only did it in part.”

Since then, the number of cases and deaths of Campinas has doubled. On Wednesday, the city extended the limit until 30 July.

Daniel Soranz, a researcher at the national biology institute run by the Fiocruz government, said Brazil’s west-center which includes an agricultural center would be the last region affected by the virus. And, looking at deaths from severe respiratory shortages, it seems that Brazil as a whole has begun to turn, he said.

“By the end of August, we must be in a much better place than today,” Soranz said.

In Sao Paulo, the most populous state in Brazil with 46 million inhabitants, the number of deaths has stabilized at a level slightly below its peak. At one of the capital’s funerals on Wednesday, Michelle Caverni buried her 88-year-old aunt, who died of COVID-19 and also suffered from pulmonary emphysema. On the same day a friend of Caverni buried her 57-year-old mother. He also died of COVID-19.

“Until you knock on your door, people are indifferent,” said Caverni, 40, a restaurant chef. “Yesterday there were 1,300 deaths due to COVID-19. Is that supposed to be a little? People say it’s only the media. I hear it every day at work. “

Most people only show moderate symptoms of COVID-19 and recover. Some, including older people or those who have old health problems, are more susceptible to severe illness, including pneumonia, or death.

Modeling by the University of Washington Institute of Health Metrics and Evaluation estimates that Brazil’s death rate will reach nearly 200,000 in November, nearly closing the gap with the US. This estimate has a wide margin of error.

“We will see how this patient known as Brazil will behave until the end of the epidemic,” said Mandetta, who was fired by Bolsonaro as minister of health in April for supporting quarantine measures for the state governor.

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Study finds Kerala great success from HCQ azithromycin in the first 500 cases | Instant News


Written Shaju Philip
| Thiruvananthapuram |

Updated: July 15, 2020, 7:56:01 am





As part of the exercise to help improve the handling of the pandemic, 500 cases reported prior to may first week in Kerala was studied. Of 500 people, three of them died, while 95.8% had only mild symptoms. (File)

The first ever clinical trial management Covid-19 patients in Kerala, the state medical Board, said that the administration hydroxychloroquine and azithromycin at early stages have improved their chances of getting better and the time for it.

As part of the exercise, to help improve processing pandemic500 cases reported prior to may first week in Kerala was studied. Of 500 people, three of them died, while 95.8% had only mild symptoms. About 18% had comorbidities, including 9.2% of diabetic and 9% with hypertension.

Explained| How developed immunity

The study showed that the average age of patients in Kerala was 34, while the figure for the whole of India was 37 and Italy 63. In addition, Kerala is much less than the proportion of patients with moderate to severe symptoms.

“This partly explains the decline in mortality rate in Kerala. Even among high-risk groups… Covid-19 does not progress to severe critical illness compared to China and Italy. This is probably due to the early receipt of confirmed cases Covid-19 in Kerala. The average number of days from the onset of symptoms to the collection of smears from the nasopharynx (for PCR test) and hospitalization in Kerala is only 1.7 days and 3 days respectively. Early administration of HCQ+Azithromycin in these high risk groups may be a factor in preventing the progression from mild to moderately-severe illness in a critical condition,” the study says.

Reading| Trying to speed up vaccine without compromising science quality, ethics: ICMR

The study showed that the average length of hospital stay in patients who received HCQ+ Azithromycin 13.51 days, compared with 14.45 days for those who received two drugs. In coronavirus also appeared in tests RT-PCR in the first category of patients in less time (12.47 days) compared with the second (14.33 days). This observation was statistically significant, the study says.

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Brazilian doctor combats Coronavirus error information after Bolsonaro praises Hydroxychloroquine for unproven drugs | Instant News


Confusion has spread in Brazil, a country devastated by coronavirus, after President Jair Bolsonaro on Wednesday praised the anti-malaria hydroxychloroquine drug, saying the drug helped him stay “very good” after being diagnosed with COVID-19 the day before.

According to a report by Bloomberg, doctors at public hospitals in the country said they had been pressured by colleagues and patients to distribute hydroxychloroquine, an unproven and potentially dangerous drug.

The situation has worsened to the point where some doctors began to circulate a petition to urge their colleagues not to prescribe drugs. Bloomberg quoted a survey from the Sao Paulo medical association that “nearly half of the nearly 2,000 doctors interviewed across the country said they also felt pressured to provide care that was not supported by scientific evidence.”

An infectious disease specialist told Bloomberg that he had been “summoned several times to stop fighting.”

“A patient with mild symptoms shouted at me and asked for a prescription, but I refused,” another doctor in Brazil told Bloomberg. “That is against our protocol and my ethical behavior.”

On June 17, the World Health Organization announced it trial terminated from hydroxychloroquine, claims the drug does not reduce mortality in coronavirus patients.

Disregarding statements from WHO, Bolsonaro immediately promoted the drug after announcing that he tested positive for COVID-19.

“For those who cheer against Hydroxychloroquine, but have no alternative, I regret to inform you that I am very good with its use and, by God’s grace, I will live for a long time to come,” tweeted Bolsonaro.

A recent video from Bolsonaro taking hydroxychloroquine collected six million views on Facebook.

The promotion of chloroquine hydroxy by Bolsonaro caused controversy before he was diagnosed with COVID-19. In mid-May, Health Minister Nelson Teich resigned because of disagreement with Bolsonaro regarding the drug.

President Trump also touted hydroxychloroquine, opposing doubts from health experts. In May, Trump said he is temporarily taking medicine as a preventative measure.

Bolsonaro, who has consistently shunned political norms, has been criticized for its handling of the pandemic. In the early stages of the outbreak, he called the corona virus a “small flu” and said his athletic past would protect him from disease.

In a social media post on Wednesday, Bolsonaro heralded his response to the virus, saying the country was successful in “sustaining life and work without spreading panic, which also led to depression and death.” Bolsonaro often argues with governors to enforce locking policies to prevent the spread of the virus, because of its impact on the economy.

The COVID-19 case has now skyrocketed in Brazil, disproportionately impacting the Afro-Brazilian nation and the low-income favela community.

On Saturdays, Johns Hopkins University reports Brazil has 39,023 new confirmed cases and 1,071 deaths. Brazil is second behind the US in a confirmed case.

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