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Hospitalizations for Food Anaphylaxis Threefold, But Deaths Decreased | Instant News


UK hospital admission rates for food-induced anaphylaxis more than tripled over the 20 years from 1998 to 2018, but the case fatality rate fell by more than half, the researchers report in BMJ.

“Cow’s milk is increasingly being identified as an allergen to fatal food reactions, and is now the most common cause of fatal anaphylaxis in children,” writes Alessia Baseggio Conrado, PhD, a biochemist from the National Heart and Lung Institute at Imperial College London, United States. Kingdom, and colleagues. “Further education is needed to highlight the specific risks that cow’s milk poses to allergic people to raise awareness among the food business.”

While recognition of the risks posed by peanut allergies has increased, people think dairy allergies are mild, says senior author Paul. J. Turner, BM BCh, PhD, allergist / immunologist at Imperial College. “This often occurs in very young children, but school-age children who still have a milk allergy tend to have a larger allergy profile, often with other allergies, including asthma, “Said Turner Medscape Medical News. “Additionally, milk is very common in our diet, and you don’t need a lot of milk to reach a decent dose of allergens.”

During the study period, 101,891 people were hospitalized for anaphylaxis; 30,700 cases (30%) were coded as being triggered by food.

This food-related income showed an increase from 1.23 to 4.04 per 100,000 population per year, with an annual increase of 5.7% (95% CI, 5.5 – 5.9; P. <0.001), write the authors.

The greatest jump was among children under 15, whose enrollment increased from 2.1 to 9.2 per 100,000 population per year, an annual increase of 6.6% (95% CI, 6.3 – 7.0) . The annual increase was 5.9% (95% CI, 5.6 – 6.2) among people aged 15 to 59 years and 2.1% (95% CI, 1.8 – 3.1) among people those aged 60 years and over.

Researchers used data from England, Scotland, Wales, and Northern Ireland to track temporal trends and age and sex distribution for admissions to hospital admissions whose primary diagnosis was anaphylaxis due to food and non-food triggers. These data are compared with nationally reported deaths.

Over a 20 year period, 152 deaths were associated with possible food-induced anaphylaxis. During that time, the case fatality rate for confirmed fatal food anaphylaxis fell from 0.7% to 0.19% (rate ratio, 0.931; 95% CI, 0.904 – 0.959; P. <0.001) and fell to 0.30% for suspected fatal food anaphylaxis (rate ratio, 0.970; 95% CI, 945 - 0.996; P. = 0.024).

Between 1992 and 2018, at least 46% of all anaphylactic deaths were thought to be triggered by peanuts or tree nuts. Among school-aged children, 26% of deaths from anaphylaxis are caused by cow’s milk.

Not surprisingly, during the study period, there was a 336% increase in prescriptions for adrenaline autoinjectors. Such prescriptions increase by 11% per year.

Global Trends

The data extends the findings of Turner and colleagues reported for England and Wales in 2014 about the entire population of England and in line with epidemiological trends in hospital admissions for anaphylaxis in the United States and Australia.

The investigators say better recognition and management of anaphylaxis could partially explain the reduction in mortality, but the increase in hospitalizations remains confusing. “Whether an actual increase in the prevalence of anaphylaxis has occurred (rather than a decrease in the threshold for admitting patients with anaphylaxis) is unclear due to a lack of evidence for an increase in the prevalence of food allergy in the UK (and elsewhere) over the same time period,” they wrote.

Ronna L. Campbell, MD, PhD, an emergency doctor at the Mayo Clinic in Rochester, Minnesota, has noted a similar trend in the United States. “Perhaps the introduction and diagnosis of anaphylaxis has increased, so the drug administration is earlier epinephrine, “Said Campbell Medscape Medical News. “So, as cases increased, earlier recognition and treatment resulted in reduced mortality.” He is not aware of any new guidelines recommending increased hospitalizations that would explain the confusing increase in admissions.

According to the study authors, the clinical criteria used to diagnose anaphylaxis in the UK did not change during the study period. Although national guidelines recommend that hospitalization of children under 16 years of age suspected of having anaphylaxis were introduced in 2011 and may have increased patient admissions, the year-over-year rate of increase has persisted since 2014. “Therefore the increase over the past five years cannot associated with the impact of the guide, “they wrote.

The study was funded by grants from the UK Medical Research Council and the UK Food Standards Agency. Two co-authors have disclosed financial links to industry outside of the jobs that are sent. Conrado did not disclose the relevant financial relationships.

BMJ. Published online February 17, 2021. Full text

Diana Swift is a medical journalist based in Toronto.

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Don’t ignore this headline: The pandemic is getting worse. What happens next is up to you. | | Instant News


Despite widespread vaccination hopes this year, experts warn the start of 2021 will be a particularly difficult time in this pandemic.

It turned out that the first two weeks were terrible.

The United States just broke the all-time record for most Covid-19 infections, hospitalizations, and reported deaths in one day:

– As of January 2, a record-high 302,506 new infections were reported in one day, according to Johns Hopkins University.

That’s an average of 3.5 people infected every second.

– As of January 6, a record high of 132,447 patients were hospitalized with Covid-19, according to the Covid Tracking Project.

Many hospitals are now overfilled, meaning even those without Covid-19 – say, victims of a car accident – may not get immediate treatment.

– As of January 12, a record-high 4,462 deaths from Covid-19 were reported in just one day, according to Johns Hopkins.

A Boeing 747 can carry about 400 passengers. That means that in one day, the US deaths from Covid-19 are the equivalent of 11 jumbo jets that crash, killing everyone on board.

Why this happened?

People let their guard down pandemic exhaustion. And many of them are fed up with getting sick prevention.

Now that the weather is cooler, more people are socializing indoors. And the coronavirus is mainly spread during close contact with other people via respiratory droplets – generated by a person talking, coughing, singing or even breathing.

Sometimes, virus particles can “lingering in the air for several minutes to several hours, “said the US Centers for Disease Control and Prevention.

“Maybe this virus capable of infecting people further than 6 feet from an infected person or after that person has left the room, “says the CDC.

Socialize indoors with anyone outside bubble – even just one friend – risky. Hanging out with lots of friends indoors can be dangerous.

“If you go to a party with five or more people, there will almost certainly be someone with Covid-19 at the party,” said Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine.

One of the reasons the coronavirus spreads so easily is because people can be contagious without knowing they are infected – and can pass the virus on without being seen or feeling sick.

The CDC estimates more than 50% of all infections are transmitted from asymptomatic people.

“This means that at least half of new infections come from people who may not be aware that they are transmitting to other people,” the agency said.

What is the difference between asymptomatic and pre-symptomatic spread?

And just as doctors predicted, vacation trips and meetings have sparked a new wave of infections, hospitalizations and deaths across the country.

The impact of the holidays may still occur across the United States over the coming weeks.

“It can take two to three weeks for patients to be sick enough to need hospitalization after they catch the virus,” said Dr. Anish Mahajan, chief medical officer at Harbor Medical Center-UCLA.

Even though Christmas was less than three weeks ago, “we’re full”.

“We don’t have ICU capacity anymore,” Mahajan said. “All the hospitals in the region are placing ICU patients in unusual places in the hospital just to find a space for them.”

Several patients have been hospitalized rest room, parking garage and gift shop.

Then there is the newly identified variant

New for 2021: The United States has confirmed at least 76 cases a very contagious variant of the corona virus first detected in Great Britain.

The US cases were found in 12 states: California, Florida, Minnesota, New York, Colorado, Connecticut, Maryland, Texas, Pennsylvania, Indiana, Wisconsin and Georgia, according to CDC data posted Wednesday.

But the real figure can be much higher because The United States lags behind dozens of other countries in the proportion of Covid-19 cases analyzed through genetic sequencing.

And The United States ranks 61 about how quickly virus samples are collected from patients, analyzed, and then sent to international databases to find new variants.

Earlier this month, a CDC official said the agency plans to do so double the number of samples sorted in mid-January – with a target of 6,500 per week.

Understanding the genetic makeup of the virus and how it changes is essential to ensure vaccines remain effective.

All viruses mutate over time, and new variants are common.

But scientists advising the British government have predicted that a variant could be up to 70% more effective at spreading from the other.

While it may be more contagious, there is no evidence that the variant first detected in the UK is more lethal or causes more severe disease, the CDC said.

But the strain first detected in Britain is not the only cause for concern.

Variant first detected in South Africa has been shown to possibly escape some of the antibodies produced by the Covid-19 vaccine.

The strain was first seen two months ago in South Africa and has been found in 12 countries. As of Thursday, it had not been detected in the United States.

Why can’t we all get vaccinated right away?

Vaccine rollout is ongoing slower than expected.

The Trump administration initially said it was purposeful to vaccinate 20 million people by the end of 2020.

It didn’t happen. Not even close.

As of Thursday morning, about 10.2 million doses of the vaccine had been administered, out of about 29.3 million doses distributed across the United States, according to the CDC.

And the two vaccines distributed in the United States today – from Pfizer / BioNTech and Moderna – require two doses for each person.

The federal government recently said it would stop holding doses held in reserve – intended to help warrant a second dose – so that more people can get their first dose sooner.

When can you get the vaccine? It depends on your health, your job and where you live.

In the coming weeks and months, the US Food and Drug Administration may authorize emergency use for other vaccines – such as those from Johnson & Johnson and AstraZeneca.

But either way, millions of Americans have to wait months before getting a vaccine.

What all of this means to you

If you want to live closer to normal (and faster), it’s time to double take security measures:

Wear a mask in public and whenever you are around someone you don’t live with. If there is a possibility of infection in your home, wear a mask at home too.

Don’t rely on a negative test result as a way to “safely” see friends or relatives. You can test negative but still be infected and contagious.

Maintain social distancing. Wash your hands frequently. And don’t think you’re invincible – even if you’re young and healthy.

“We saw severe illness among healthy young adults without a clear underlying cause, “said Hotez.

“Is it because … higher doses of the virus, whether they have genetic changes they don’t know – we don’t understand,” he said.

“So, we can’t predict with certainty who will handle this virus well, and who will not.”

CNN’s Elizabeth Cohen, Maggie Fox, Michael Nedelman, and Amanda Watts contributed to this report.

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COVID-19 Live Update: Firefighters are forced to drive ambulances in the UK as cases of the coronavirus increase | Instant News


NEW YORK (WABC) – The coronavirus continues to rage out of control in London, with the mayor declaring a “major incident.”

The designation is usually reserved for the most severe crises such as terrorist attacks.

In some districts, the virus infects 1 in 20 people.

Firefighters have been asked to help pilot the ambulance.

Elective surgery was delayed, but some admissions could not be delayed.

Britain has vaccinated more people and authorized more vaccines than its European neighbors, but launching a vaccine in that country will take months.

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Here are more headlines for the day:

The COVID case closes airspace
A person tested positive for the coronavirus on Sunday at the FAA’s control center in Leesburg, Virginia.

The facility handles some of the most complex airspace in the country. By Sunday afternoon, most of the air traffic above 18,000 feet had cleared from Carolina to New Jersey.

Studies show the Pfizer vaccine works against variants of the coronavirus
New research points to Pfizer’s COVID-19 vaccine can protect against mutations found in the two more contagious variants of the corona virus which erupted in England and South Africa.

This study is preliminary and does not look at the other two main vaccines used in the West – Moderna and AstraZeneca. But it’s reassuring, given the question of whether the virus can mutate to beat the shot the world has hoped for.

5 NYC vaccination sites will open Sunday, including two 24-hour sites
In an effort to end the coronavirus pandemic, New York City is poised opened five new vaccination centers Sunday, and not so fast. The most recent citywide positive rate is over 6.5%.

Britain invited more than 80’s to get a viral vaccine
Thousands of people aged 80 and over have started accepting invitations to get a coronavirus vaccine in Britain, officials said on Sunday, as Britain scaled up its national vaccination program in an attempt to meet its target of inoculating some 15 million people by mid-February.

More than 600,000 invitations will arrive at doors across the UK this week, asking the elderly to register for the injection at a new mass vaccination center near them. So far, the government has given the first dose of the vaccine to more than 1.2 million people.

Quarantine Lieutenant Governor of the Republic of Indonesia
Rhode Island Lieutenant Governor Daniel McKee is under quarantine at home after coming into close contact with someone who later tested positive for COVID-19, officials said Saturday.

The lieutenant governor was aware of close contact Saturday morning, since testing negative and showing no symptoms, officials said. He will continue to be tested and will remain in quarantine until midnight on January 12, officials said.

McKee is set to serve the remaining two years of Governor Gina Raimondo’s tenure after Raimondo is appointed as Democratic Joe Biden’s minister of commerce for Biden.

Stony Brook University completes administration of 100% of the initial allocation of the COVID-19 vaccine
SUNY’s Chancellor said the three hospitals run by Stony Brook University finished managing 100% of their initial COVID-19 vaccine rationing on Friday. Frontline health care workers at Downstate Medical, Upstate Medical, and Stony Brook University Hospital are now starting to receive second doses of their vaccine. The Chancellor congratulates the Stony Brook University team for their good work.

Queen Elizabeth II, Prince Philip received the COVID-19 vaccination
Queen Elizabeth II and her husband, Prince Philip, have received their COVID-19 vaccination, royal officials said Saturday.

Buckingham Palace officials said in a statement that the 94-year-old king and Philip, 99, received their injections Saturday, joining some 1.5 million people in Britain who have been given the first dose of the vaccine.

The injections were carried out at Windsor Castle, where the queen and her husband spent their time during the British lockdown.

National coronavirus update

The latest national coronavirus figures continue to paint a bleak picture. More than 371,000 deaths, with nearly 2 million cases. California reports its deadliest day with a staggering death toll of nearly 700. Temporary morgues quickly fill up.
One Southern California hospital can accommodate a COVID-19 patient – it cannot provide space for just one more person. The waiting time to bring in some of Southern California’s sickest people is up to 17 hours. More than six million doses of vaccine have been given – only 30% of the doses distributed.

The Cardinals’ home stadium is used as a mega testing and vaccination site
The Arizona Cardinals football team’s home stadium will be a large testing and vaccination site capable of delivering up to 12,000 doses daily. The move comes as Maricopa County begins offering the vaccine to those in group 1b next week. A group that includes law enforcement, teachers, child care workers and those aged 75 and over. Volunteers with the Blue Cross Blue Shield of Arizona will provide the needed staff. State health officials believe they are prepared to meet the demand.

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The US is approaching 350,000 coronavirus deaths as some hospitals hit a ‘breaking point’. Get the latest number | National news | Instant News


The US has 20 million total infections and close to 350,000 deaths from Covid-19 in the first day of 2021 – evidence of the grim reality that continues into the new year.

More people have died across the US than anywhere else: nearly 348,000 Americans since the start of the pandemic. Another 115,000 could die over the next month, according to projections from the University of Washington Institute for Health Metrics and Evaluation.

By comparison, more than 77,500 people died in December, the country’s deadliest month.

The hospitalizations were at the highest level they had ever experienced. The US reported a record 125,379 Covid-19 patients hospitalized nationwide on Thursday, according to the Covid Tracking Project. That number fell slightly on Friday, with 125,057 hospitalizations reported – a 163% increase from two months ago.

A California doctor said the hospital had reached “breaking point”.

“We are also worried that at some point in time we will have difficulty finding places and staff to care for all the sick patients who come with Covid-19 who really need our help,” said Dr. Nicole Van Groningen of Cedars-Sinai Medical Center in Los Angeles.

Friday’s achievement also means the country has recorded the most Covid-19 infections so far. The amount is twice the reported No. 2 India and nearly three times that of No. 3 Brazil.

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Update: South Carolina governor tests positive for virus | Business | Instant News


California records an average of nearly 44,000 new confirmed cases each day and has recorded 525,000 in the past two weeks. An estimated 12% of those who test positive end up in hospital. That translates to 63,000 hospitalizations from the last 14 days of the case. The current figure is 17,190.

PHOENIX – The death toll in Arizona from the coronavirus outbreak passed 8,000 on Tuesday as the state reported an additional 153 known deaths, the second highest daily increase during the pandemic.

The state has seen 8,125 total deaths.

The Health Services Department reported an additional 5,869 known cases of COVID-19 as of Tuesday, raising the state’s total to 467,215 confirmed cases.

According to the country’s coronavirus dashboard, there were 4,019 virus-related hospitalizations as of Monday, the latest in a series of pandemic highs recorded this month during the fall spike that now continues into winter.

MILAN – The number of new COVID-19 cases in Italy rose by 13,318 on Tuesday, with 201 cases requiring intensive care, as Italy heads for a national partial closure for the Christmas holidays.

The Health Ministry said the daily death toll remained at 601, bringing the total pandemic in Italy to 69,842. Hospitalizations fell below 25,000, with 2,687 people in intensive care – 43 fewer than the day before.

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