Many people are hoping that getting a Covid-19 vaccine will mark an immediate return to normal: more masks, more distancing, safe dining and big hugs with friends. The reality is more complicated. For now, people who have been vaccinated must navigate decision-making in a world where the vaccinated and the unvaccinated will coexist for months, even within the same household. So what should and shouldn’t you do? The U.S. Centers for Disease Control and Prevention is expected to issue guidelines soon. “We are taking the time to get it right and will be posting the tips soon,” CDC director Rochelle Walensky said on Friday. “We want to make sure the communication is crystal clear.” In the meantime, other experts are somewhat divided. Some say people who have been vaccinated can and should have a lot more freedom, and think it is important to stress this to encourage more people to get vaccinated. Others are more conservative, saying it is too early to abandon too many precautions without more conclusive data on the effectiveness of vaccines against new variants and the potential risk of vaccinated people spreading the virus to unvaccinated people. Most agree that until we get closer to herd immunity – when a substantial majority of the population is protected by vaccination or natural infection so the virus cannot easily spread – wearing masks , social distancing and avoiding crowded gatherings indoors should be common practice in public spaces. “Particularly during these several months when vaccination coverage is low, we are still learning about the variants, and we still have to know this further transmission, the public health message is really to maintain these behaviors,” explains Chris Beyrer, professor. of Epidemiology at the Johns Hopkins Bloomberg School of Public Health. “Until we get out of it. We’re not out of it yet. A doctor shows his vaccination record. Photo: chandan khanna / Agence France-Presse / Getty Images Here are the scientists’ recommendations on how to assess risks. Can vaccinated people meet other vaccinated people? Most experts agree that once fully vaccinated – two weeks after your second dose of Pfizer or Moderna vaccine or about a month after the Johnson & Johnson vaccine – it is safe to meet other fully vaccinated people inside without. mask or distance. But gatherings should be small. Getting together with other vaccinated people is “scientifically very safe,” says Paul E. Sax, clinical director of the division of infectious diseases at Brigham and Women’s Hospital in Boston. Nothing is 100% effective, but “getting together with other vaccinated people is very close,” he says. “I don’t think people should run into a crowded bar where people are yelling at each other,” he says. “But the kind of socializing that is part of human nature and that has been suspended for a lot of people – it can resume.” The larger the group, the more risky the interaction, because you can’t verify that everyone is vaccinated and you don’t know what their exposures are, says Leana Wen, emergency physician and professor of public health at the University. George Washington in Washington, DC. “I’m talking about another couple or maybe two other couples at most,” says Dr. Wen. Monica Gandhi, an infectious disease physician and professor of medicine at the University of California, San Francisco, is less conservative, saying people who have been vaccinated should feel more comfortable. “They can organize dinners. They can go to a restaurant. They can go to the movies, ”she said. But she notes that even those vaccinated will have to adhere to mask and distance requirements in these public places until we achieve herd immunity. What if adults are vaccinated but children are not? There is currently no licensed vaccine for children and adolescents under the age of 16. “This will be one of those issues that families will have to grapple with and exercise caution with,” says Dr Beyrer. There is a significant difference between young children and adolescents or adolescents in terms of transmitting the virus and getting the disease, says Dr. Sax. Adolescents catch and transmit Covid-19 in the same way as young adults, while young children do not contract the symptomatic disease as often and do not seem to transmit as much. “Each family and group of friends will make decisions based on their own tolerance for risk,” says Dr. Sax. People who are immunocompromised and their families should be more careful because vaccines in general may be less effective in them, says Dr. Sax. Dr. Wen says she recommends families continue to take playtime precautions when adults are vaccinated but children are not. “If these families also team up with other families, it’s a risky scenario that I wouldn’t recommend at this time,” says Dr Wen of indoor gatherings. “They could be an asymptomatic carrier who would then pass it on to their children. And if the kids are in school or daycare, there might be a further gap from that. What is the final question on whether vaccinated people can transmit the virus to unvaccinated people? Recent studies have shown that vaccination reduces asymptomatic infection by more than 80% compared to unvaccinated people and that nasal viral loads are low and potentially non-infectious, says Dr Gandhi. But other experts say the evidence is preliminary and more conclusive evidence is needed. And the new variants raise additional questions about the effectiveness of vaccines. What activities should I prioritize after being vaccinated? Schedule any routine medical and health appointments you’ve postponed, says Dr. Wen. Get your colonoscopy, mammogram, or dental cleaning. Plan elective surgery. “Anything like that, you should take it back because you’re well protected,” says Dr Wen. What about travel? Once you’re vaccinated, traveling itself is less risky, says Dr Wen, as is staying in hotels or going to restaurants, as long as you follow safety protocols. But be careful about how you meet people once you get to your destination, she says, especially if they aren’t vaccinated or if they live in an area with high transmission rates. Is it safe for my elderly parents to travel for a visit? If the grandparents are now fully vaccinated, they should be able to travel safely for a visit. “The trip itself is very low risk,” says Dr. Wen. “If they follow precautions like wearing a mask, the risk of them contracting the coronavirus and passing it on to the rest of the family is extremely low and the payoff is huge. People can’t wait to see their families. But always weigh the specifics of your situation. If you have an older unvaccinated teenager and an elderly, frail grandparent, consider more precautions, says Gregory Poland, director of the Mayo Vaccine Research Group in Rochester, Minnesota. Which activities have a lower and higher risk, even after vaccination? People who have been vaccinated may feel comfortable performing quiet indoor activities where people usually need to be masked and kept away, such as visiting an infrequently visited museum, says Dr Sax. Outdoor activities are even safer. High-risk situations include indoor restaurants, bars, gyms, and places of worship, where people sing and talk. “We don’t want to push the boundaries of what vaccines can do before the number of cases drops,” says Dr Sax. He and his doctor wife are both fully vaccinated but won’t dine in restaurants until the number of cases and hospitalizations are significantly lower, he says. Airports in Paris and Singapore, along with airlines such as United and JetBlue, are experimenting with apps that verify travelers are not Covid before boarding. The WSJ is heading to an airport in Rome to see how a digital health passport works. Photo credit: AOKpass —Betsy McKay contributed to this article. Write Sumathi Reddy at [email protected] Share your thoughts If you’ve been vaccinated, what are you comfortable doing? Copyright © 2020 Dow Jones & Company, Inc. All rights reserved. 87990cbe856818d5eddac44c7b1cdeb8.
Illustration by Elias Stein Text size For much of the past year, travel-related companies have been posters for the companies that have been most disrupted by Covid-19. Although bets on an economic recovery rose, stocks remained severely depressed. Recently, they have shown a bit of pizzazz. The US Global Jets exchange-traded fund is up 17% this year, compared to 3% for the S&P 500 index. The latest bump came as vaccines were more widely distributed and airlines moved. started to see an improvement, albeit modest, in operational parameters. Investors seem increasingly optimistic that travel will recover significantly as the pace of vaccinations picks up. Airlines are lining up more money from Washington, with $ 14 billion in aid likely as part of the $ 1.9 trillion stimulus bill. Domestic traffic, revenues and bookings are all increasing, says UBS analyst Myles Walton, who sees the situation improving further. Investors are also betting that domestic flights will rebound before international routes and that leisure travel will recover before business. The biggest winners of the year were US-focused carriers such as Spirit Airlines and JetBlue Airways, up 48% and 29%, respectively. Norwegian Cruise Line Holdings, Carnival and Royal Caribbean Group also grew at least 23% in 2021. Carnival has raised capital twice this year, selling $ 1 billion in stocks and $ 3.5 billion in non-debt. guarantees to consolidate its liquidity. Unsecured debt means lenders haven’t demanded collateral, betting Carnival will be able to repay its loans out of profits. Equity investors want to own part of the business and don’t see it going into insolvency. Inflation Fix Last Week The S&P 500 had its biggest day since June Monday, with all 11 sectors up, led by the 3.2% rise in tech. But questions about bond yields, inflation and the Federal Reserve persisted. Volatility rose, as tech stocks slipped, then indexes plunged after the Fed’s Jerome Powell stuck to his easy money policy, then rallied despite big jobs numbers that did raise bond yields. Over the week, the Dow industry rose 1.8% to 31,496.30; the S&P 500 edged up 0.8% to 3,841.94; and the Nasdaq Composite fell 2.1%, to 12,920.15.A Vaccine Deal The Food and Drug Administration has approved the Johnson & Johnson Covid-19 vaccine, while the White House negotiated a deal with Merck for the ‘help produce it. President Biden announced that there will be enough vaccine to immunize all American adults by the end of May. He also prioritized teachers and school staff for vaccinations by the end of March. Texas and Mississippi abandoned mask mandates and opened businesses; Biden called the movements “Neanderthal”. The relief bill, meanwhile, has been sent to the Senate and discussions continue on the minimum wage. Climate change The American Petroleum Institute has approved a price for carbon emissions. Exxon Mobil has added two new board members, activist investor Jeffrey Ubben and former Comcast CFO Michael Angelakis, leaving out activist Engine No.1, who had sought four seats. And Texas’ largest cooperative electricity supplier, Brazos Electric Power, has filed for bankruptcy after being hit by $ 2.1 billion in bills following the recent freeze. the “gamification” of stock trading – a response to the GameStop episode – and the increasing concentration of retail execution. Almost all of Biden’s nominees have been approved. The exception: Neera Tanden, whose leadership appointment in the Office of Management and Budget was withdrawn by the White House after failing to get the votes. Buffett on Berkshire Hathaway’s Warren Buffett buyouts in his annual letter was down on fixed income and up on share buybacks, praising one of the company’s “four gems”, Apple, for its buyback program. Berkshire has stepped up its own buyouts. Annals of Deal-Making It’s been a great week for Apollo Global Management. The private equity giant pocketed Las Vegas Sands for $ 6.3 billion as the casino company left Vegas; said he was taking private Michaels craft chain for $ 3.3 billion, the chain’s second buyout; and talked about taking the online photo company Shutterfly public through a PSPC. And it found itself competing for the assets of bankrupt Greensill Capital, after SoftBank-backed fintech filed for insolvency in the UK and German regulators took the case to court. Write to Nicholas Jasinski at [email protected] and to Daren Fonda at [email protected]
Cipla announced that its subsidiary, Teluk Cipla FZ LCC (Cipla Bay) is expanding its partnership with Alvotech for the marketing and distribution of four biosimilar drugs in Australia and New Zealand.
As part of this strategic alliance, Cipla Bay will be responsible for commercialization of the patented biosimilar from the biologic drug brands, Aflibercept (Eylea), Ustekimumab (Stelara), Denosumab (Prolia, Xgeva) and Golimumab (Simponi). It is a leading product covering therapeutic categories across immunology, osteoporosis, oncology, and ophthalmology (ex.
Aflibercept is indicated for NAMD and other serious eye diseases).
This product is developed and manufactured by Alvotech and will be distributed by Cipla Bay through the Australian and New Zealand distribution network. These innovative products account for US $ 700 million in 2020 aggregate sales in Australia.
Cipla Bay previously signed a similar agreement with Alvotech in July 2019 for the commercialization of AVT02, a biosimilar adalimumab, in certain emerging markets.
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The pandemic travel crisis that has hit tourism dependent economies may only be beginning. Travel destinations from Thailand to Iceland were hoping that the Covid-19 vaccines would allow countries to reopen their borders and lead to a much-needed recovery in 2021. Now, with the vaccine rollout delayed in some places and the emergence of new viral strains, it seems more likely that international travel could be blocked for years. After declaring that 2020 was the worst year on record for tourism, with a billion fewer international arrivals, the United Nations World Tourism Organization says the prospects for a rebound for 2021 have deteriorated. In October, 79% of experts polled by the agency believed that a rebound in 2021 was possible. Only 50% said they believed in January, and around 41% did not believe travel would reach pre-pandemic levels until 2024 or beyond. James Sowane, who owns a transport company for tourists in Fiji, called a staff meeting earlier this month and told employees to start looking for other jobs. He recently took advantage of a government aid package and brought home laid-off workers, optimistic vaccines could trigger a resumption of travel as early as April. But now Mr Sowane doesn’t think tourists will be back until next year, and he and his wife can’t afford to continue paying salaries at their business, Pacific Destinations Fiji. He borrows from his bank to keep a few basic employees. .
SERRANA, Brazil – As Covid-19 rages across Brazil, killing nearly a quarter of a million people, high infection rates have turned the country into a perfect vaccine testing ground.
Now, Brazil is using its misfortune to help answer one of the pandemic’s most pressing questions as millions of people are being inoculated around the world: Can someone being vaccinated still transmit the virus?
In the first trial of its kind globally, researchers on Wednesday started a project to vaccinate the entire adult population of Serrana, the worst-hit commuter city of 45,000 people in the state of São Paulo, before any other state.
By immunizing everyone in the city through a controlled stage, they say the results will help global scientists understand how quickly a vaccine can curb. coronavirus pandemic. And inoculating entire cities would counter the growing anti-vaccination movement in Brazil and demonstrate the broader benefits of mass immunization, such as the rapid economic recovery expected with Serrana’s rapid reopening.
“This will give us information on the percentage of people who need to be vaccinated to achieve herd immunity – nobody knows this yet,” said Marcos Borges, professor of medicine at the University of São Paulo near Ribeirão Preto who led the study.