Tag Archives: Lupus

Health service providers urge to stop using hydroxycholoroquine for COVID-19 | Instant News


The sacred oaths taken by doctors during graduation from medical school to “First do no harm,” the first words of the Hippocratic Oath, provide a powerful impetus for comments that have just been published in The American Journal of Medicine.

Researchers from Florida Atlantic University’s Schmidt School of Medicine and collaborators from the University of Wisconsin School of Medicine and Public Health urge all health care providers to prioritize compassion with reliable evidence about efficacy and security.

They recommend a moratorium on prescription chloroquine or hydroxychloroquine, with or without azithromycin, to treat or prevent COVID-19, with the exception of getting the evidence needed in randomized trials and loving use.

Despite the fact, or maybe partly due to the fact that there are no therapeutic or preventative measures for the COVID-19 pandemic in the United States, which accounts for less than 5 percent of the world’s population and about 30 percent of cases and deaths, prescription drugs are widespread nine times bigger than in the last few years.

This widespread use leads to national deficiencies in patients with lupus and rheumatoid arthritis, for whom hydroxychloroquine has been an approved indication for decades. These patients cannot fill their prescriptions.

On March 28, the US Food and Drug Administration (FDA) issued an emergency use permit for chloroquine and chloroquine hydroxy for the treatment of COVID-19. However, on April 24, the FDA issued a drug safety communication warning regarding chloroquine hydroxy disorders and heart rhythm disorders that can cause sudden cardiac death.

If this drug needs to be prescribed for patients with COVID-19, initial evaluation and serial monitoring are an absolute necessity. “

Richard D. Shih, M.D, Study First Author and Professor of Emergency Medicine, Florida Atlantic University

Shih is also a division director and founding program director for emergency medicine residency programs at FAU’s Schmidt College of Medicine.

Furthermore, the authors suggest that the convincing safety profile of chloroquine may be more real than it really is.

Data on safety comes from decades of prescription by healthcare providers, especially for their patients with lupus and rheumatoid arthritis, both of which have a greater prevalence in young and middle-aged women, whose risk of fatal cardiac outcomes due to hydroxychloroquine is very convincing. low.

In contrast, the risk of hydroxychloroquine for patients with COVID-19 is significantly higher because of fatal cardiovascular complications due to these drugs is much higher in older patients and those who have heart disease or risk factors, both of which are mostly male .

In basic research, hydroxychloroquine and chloroquine are structurally related and have similar mechanisms to inhibit the virus that causes COVID-19. Despite their structural similarities, in vitro, hydroxychloroquine seems to be more effective.

Additionally, when used for lupus and rheumatoid arthritis, hydroxychloroquine has fewer side effects, less drug interactions and is less toxic in overdoses.

The authors note that the evidence currently available is limited to eight published studies, five on hydroxychloroquine alone; two in chloroquine hydroxy plus azithromycin; and one in both in combination or alone.

Of these only three were randomized trials enrolling 225, 62, and 30 patients – all of them too small to provide reliable evidence. All three tested hydroxychloroquine alone versus the standard of care in China.

One showed no significant difference in cleansing the virus at 28 days, second, there was no difference in cleansing the virus at seven days, and third, some improvements in fever, coughing and chest computed with tomographic findings.

“With regard to hypothesis testing, only large-scale randomized trials with sufficient size, dosage and duration can reliably detect the most reasonable small to moderate effects, which can have enormous clinical and public health impacts,” said Charles H. Hennekens, MD, Dr.PH, senior writer, first professor Sir Richard Doll and senior academic advisor at FAU’s Schmidt College of Medicine.

Source:

Journal reference:

Shin, R D., et al. (2020) Hydroxychloroquine for Coronavirus: Urgent Need for Prescription Moratorium. American Journal of Medicine. doi.org/10.1016/j.amjmed.2020.05.005.

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What we know and don’t know about hydroxychloroquine | News | Instant News


NASHVILLE, TN (WSMV) – The president said he used Hydroxy-Chloroquine as a preventative measure and a Vanderbilt pharmacist explained what we know about the drug.

Hydroxychloroquine is a drug commonly used to treat and prevent malaria. It can also treat arthritis and lupus.

U.S. Food and Drug Administration has approved its use against malaria, lupus, arthritis, but not COVID-19.

President Donald Trump said on Monday that he used drugs to try to prevent coronavirus. But scientists are still studying the effects of drugs on this disease.

“In some poorly conducted studies it has been shown to reduce the amount of virus circulating in patients but does not show significant changes in the clinical course or patient mortality,” Pratish Patel, who is a pharmacist at Vanderbilt University Medical Center, said. .

Patel said the researchers still have a lot to learn about the effects of the drug on COVID-19.

“We are trying to understand whether Hydroxychloroquine affects how much a patient’s infection is. How well it works to reduce the amount of time a patient experiences symptoms and whether it reduces the mortality rate,” Patel said.

Like many drugs, there are side effects.

“This can be potentially dangerous. Especially in patients who already have a heart condition that makes them vulnerable and arrhythmia,” Patel said. “Unfortunately we don’t have the rigorous clinical trials we need to be able to consider hydroxychloroquine as a modifier of gamers in any way.”

Patel said we were still a few months away to find out if this drug was effective or not.

The president received approval from White House doctors to start taking medicine about a week and a half ago.

The FDA recommends that you always consult your doctor before taking any medication.

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Lupus patients must be extra careful about Covid-19, said the doctor, Health News, ET HealthWorld | Instant News


Hyderabad: Patients with autoimmune diseases must be extra careful about their health during the Covid-19 pandemic, doctors in the World Lupus Day.

Lupus or Systemic lupus Erythematosus (SLE) is a chronic autoimmune condition in which the immune system attacks its own tissues, weakening the body.

Because Lupus patients are given immune-suppressing drugs, they will be at higher risk of contracting such infections corona virusespecially in the case of old age and other comorbidities.

Global findings show people in the category of senior citizens who suffer from autoimmune diseases are at high risk of contracting Covid-19.

“The treatment protocol prescribed for Lupus patients can also increase the risk of opportunistic infections or cause complications. Therefore, prevention is one of the most important tools for these patients to fight Covid-19,” said Dr. Aruna Sree Malipeddi, Consultant. Rheumatologist, Continental Hospital.

Lupus affects one in every thousand people in India, the majority of which are women. The male-female ratio of people affected by lupus is estimated at 1:11. This may be a life-threatening disease that affects women in the 15 to 45 years age group.

“Among Lupus patients, it is important to watch out for common symptoms of infection, such as fever, difficulty breathing, dry cough, and chest discomfort. People who experience all kinds of illnesses, including symptoms of common respiratory conditions, must remain at home. Home and “High-risk symptoms require immediate medical attention,” Dr. Aruna said.

Such patients need not be afraid to come to the hospital if the situation requires the hospital to take adequate precautions and there is no need to panic.

A person with lupus, if tested positive for coronavirus, should not stop taking lupus unless the doctor recommends it. Suddenly stopping treatment can cause symptoms, which adds stress to the body.

The doctor said that patients who were already taking steroids should not stop taking the medicine suddenly and had to discuss with the doctor about the dosage. There is a lot of discussion about hydroxychloroquine (HCQ) for treating Covid-19 and its side effects on heart rhythm. Lupus patients should continue to use HCQ as advised by their doctor.
According to Dr. V. Sarath Chandra Mouli, Senior Consultant Rheumatologist, AKIMS Hospital, Lupus can affect one or many organs such as the skin, joints, muscles, kidneys, nerves, brain, heart and lungs.

This disease is believed to be caused by a combination of factors such as genetic, hormonal and environmental. However, it is not a contagious disease.

“In Lupus patients, antibodies (a type of protein), instead of protecting them from viruses, bacteria and other foreign bodies, attack their own tissue cells. Common symptoms are significant hair loss, fever, recurrent oral ulcers, red rashes on the cheeks (butterfly rash), fatigue, weight loss, joint pain and swelling, “he said.

Extreme fatigue can be very troublesome in some Lupus patients who are even moderately controlled and hence adequate rest is very important. Regular exercise, physiotherapy, yoga, meditation, positive thinking, and relaxation therapy also help.

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