Tag Archives: Microbiology

Science Advisory Board | Instant News


Science Advisory Board<br />

COVID-19 has long-term effects on the biotechnology industry

January 5, 2021 – The COVID-19 pandemic will have far-reaching and lasting effects on the biotechnology industry, according to speakers at a January 5 presentation held ahead of the virtual Biotech Showcase being held on January 11-15. Biotech companies have been swirling around on a large scale pursuing infectious disease research – and not all of them will succeed.
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An allergic reaction to the COVID-19 vaccine should not stop vaccination

January 4, 2021 – The COVID-19 vaccine currently approved for emergency use by the US Food and Drug Administration (FDA) is safe even among people with food or drug allergies, according to allergists from Massachusetts General Hospital. A review of all relevant information is published on Journal of Allergy and Clinical Immunology: In Practice on December 31st.
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Top 10 ScienceBoard stories for 2020

21 December 2020 – For many of us, 2020 didn’t go according to plan. The emergence of the COVID-19 pandemic has drastically changed our daily lives. Right here at ScienceBoard.net, we have provided our readers with timely and evidence-based information regarding COVID-19, as well as many other topics in the biopharmaceutical and life sciences industry.
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The FDA issued the EUA for the Moderna COVID-19 vaccine

18 December 2020 – Just one day after the committee’s favorable recommendation, the US Food and Drug Administration (FDA) has issued an emergency use authorization (EUA) for the COVID-19 messenger RNA (mRNA) vaccine from Moderna. The company’s mRNA-1273 vaccine is now the second COVID-19 vaccine on the US market, after vaccines from Pfizer and BioNTech were administered EUA last week.
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New discoveries could produce broad-spectrum antivirals

18 December 2020 – Scientists have identified key human genes that cells need to consume and destroy viruses. Research results are published in Natural on December 16 and could demonstrate new treatments to target viral infections, including COVID-19.
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The FDA committee voted in favor of the Moderna COVID-19 EUA vaccine

17 December 2020 – Moderna’s COVID-19 messenger RNA (mRNA) vaccine candidate, mRNA-1273, received favorable recommendations on December 17 from an advisory committee for the US Food and Drug Administration (FDA). The OK Committee means that mRNA-1273 may receive emergency use authorization (EUA) within a few days.
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The new immunotherapy supports the polio vaccine to treat cancer

17 December 2020 – As if we needed another reason to get vaccinated, researchers have developed technology that uses the polio vaccine to help treat cancer in those who later develop the disease. The technology, developed at Duke University and developed by Istari Oncology, uses the antigen produced by the polio vaccine to trigger the immune system to eat away at targeted cancer cells.
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The genes provide new targets for COVID-19 therapy

15 December 2020 – Genes associated with antiviral immunity and lung inflammation have been linked to severe cases of COVID-19 in a new genome analysis carried out in the UK. The result, published in Natural on December 11, revealed new therapeutic targets for drug reuse and development efforts.
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Global health R&D has stalled as resources shifted to COVID-19

December 14, 2020 – The current coronavirus pandemic has slowed progress in research and development (R&D) on neglected diseases and other long-term global health challenges by disrupting ongoing research and directing resources to the work of COVID-19, according to a new report released on December 11. by the nonprofit Global Health Technologies Coalition.
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The FDA issued the EUA for Pfizer’s vaccine, BioNTech COVID-19

12 December 2020 – The US Food and Drug Administration (FDA) has issued an emergency use authorization (EUA) for the Pfizer-BioNTech COVID-19 vaccine. This step comes after the FDA’s Vaccines and Biological Products Advisory Committee issued positive recommendations for the vaccine.

Google’s DeepMind is making a quantum leap in solving the problem of protein folding

11 December 2020 – Artificial intelligence has made breakthroughs in protein structure prediction. The results come as part of the 14th Critical Assessment of Structure Prediction, a friendly contest and conference organized by the Protein Structure Prediction Center with sponsorship from the National Institute of General Medical Sciences, part of the US National Institutes of Health.
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Science Advisory Board | Instant News


Science Advisory Board<br />

The FDA committee voted in favor of the Moderna COVID-19 EUA vaccine

17 December 2020 – Moderna’s COVID-19 messenger RNA (mRNA) vaccine candidate, mRNA-1273, today received favorable recommendations from the advisory committee for the US Food and Drug Administration (FDA). The OK Committee means that mRNA-1273 may receive emergency use authorization (EUA) within a few days.
Discuss

The new immunotherapy supports the polio vaccine to treat cancer

17 December 2020 – As if we needed another reason to get vaccinated, researchers have developed technology that uses the polio vaccine to help treat cancer in those who later develop the disease. The technology, developed at Duke University and developed by Istari Oncology, uses the antigen produced by the polio vaccine to trigger the immune system to eat away at targeted cancer cells.
Discuss

The genes provide new targets for COVID-19 therapy

15 December 2020 – Genes linked to antiviral immunity and lung inflammation have been linked to severe cases of COVID-19 in a new genome analysis carried out in the UK. The result, published in Natural on December 11, revealed new therapeutic targets for drug reuse and development efforts.
Discuss

Global health R&D has stalled as resources shifted to COVID-19

December 14, 2020 – The current coronavirus pandemic has slowed progress in research and development (R&D) on neglected diseases and other long-term global health challenges by disrupting ongoing research and directing resources to the work of COVID-19, according to a new report released on December 11. by the nonprofit Global Health Technologies Coalition.
Discuss

The FDA issued the EUA for Pfizer’s vaccine, BioNTech COVID-19

12 December 2020 – The US Food and Drug Administration (FDA) has issued an emergency use authorization (EUA) for the Pfizer-BioNTech COVID-19 vaccine. This step comes after the FDA’s Vaccines and Biological Products Advisory Committee issued positive recommendations for the vaccine.

Google’s DeepMind is making a quantum leap in solving the problem of protein folding

11 December 2020 – Artificial intelligence has made breakthroughs in protein structure prediction. The results come as part of the 14th Critical Assessment of Structure Prediction, a friendly contest and conference organized by the Protein Structure Prediction Center with sponsorship from the National Institute of General Medical Sciences, part of the US National Institutes of Health.
Discuss

The FDA committee approved the transfer of Pfizer, the BioNTech COVID-19 vaccine to EUA

December 10, 2020 – Pfizer-BioNTech’s COVID-19 vaccine candidate, BNT162b2, passed an important milestone today when the US Food and Drug Administration (FDA) advisory committee determined that the candidate’s benefits in preventing COVID-19 outweigh the risks. The committee’s advice is likely to lead to the issuance of an emergency use authorization (EUA) for vaccines by the FDA within days.
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The new study found the SARS-CoV-2 antibodies disappeared rapidly

8 December 2020 – Antibodies developed after being infected with the SARS-CoV-2 virus disappeared rapidly, according to an analysis published in Immunology Science on December 7th. These findings may suggest that SARS-CoV-2 infection may not offer long-term immunity from subsequent reinfection with the virus.
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The new universal flu vaccine targets conserved areas of viral surface proteins

December 7, 2020 – A new universal influenza vaccine has been developed that targets the surface protein stem of the influenza virus rather than the head. This vaccine, which is capable of neutralizing various strains of influenza, was evaluated in a phase I clinical study whose results were published in Natural Medicine on December 7th.
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Regulatory Roundup: The appointment is made before the end of the year

December 7, 2020 – This week’s Regulatory Roundup covers activities from November 30 to December 4 and is filled with breakthroughs, orphans, and rare disease appointments from the US Food and Drug Administration and the European Medicines Agency. Several cancer, immunotherapy, and vaccine companies also submitted biological licensing applications to advance their candidates.
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Global report: Germany may extend lockdown as Covid cases in Italy soar | World News | Instant News


GermanPartial lockdowns can be extended after the end of the month and hospital in some sections Italy nearing breaking point as Covid-19 cases continued to surge in both countries, despite positive signs in other countries Europe.

New daily coronavirus cases at German hit a record 23,542 on Friday, the Robert Koch Institute for infectious diseases reported, prompting government spokesman Stefan Seibert to say measures “are not expected to be relaxed” over the next week.

Federal and regional leaders will meet on Monday to discuss whether the closure of all gyms and entertainment venues in the country has slowed the spread of the disease, but the health minister, Jens Spahn, said it was too early to say.

“We will see in the coming days whether they make a difference,” said Spahn. Winter gatherings and celebrations such as a Christmas party at the office are unlikely to continue.

The Christmas market, the traditional St Martin Day parade and the German carnival season, which was supposed to start this week, have all been canceled, while more than 300,000 school students are in quarantine along with some 30,000 teachers.

South side Italy The city of Naples, meanwhile, is bracing for further restrictions as hospitals risk becoming overwhelmed by new cases, with medics forced to carry oxygen tanks outside to treat desperate patients waiting in their cars.

“The situation in Campania is out of control,” said Italy’s foreign minister, Luigi Di Maio, after a video emerged showing an 84-year-old man dying in a hospital bathroom where he had been waiting for a Covid test. “We need urgent restrictions… people are dying.”


Hundreds of people from Campania have traveled to neighboring Lazio seeking urgent medical assistance as political clashes continue over whether to impose a complete lockdown on the region.

Campania is expected to be upgraded to the “red zone” from Sunday, meaning people will have to stay at home unless going out for work, shopping or medical reasons, and bars, restaurants and most shops will close.

Italy’s alternative approach to a crippling national lockdown imposed during the first wave of this spring has had little success so far, with total infections past the millions this week and cases increasing by more than 30,000 per day.

Confirmed case in Portugal surpassing 200,000 with new daily infections hitting a record high of 6,653 and a new record 2,799 Covid patients in hospitals. The state of emergency that will last until November 23 will likely be extended.

“By the time we reach the peak of the disease, it will still take weeks to see a drop in hospital demand and even more weeks to reduce the number of deaths,” the health minister, Marta Temido, told a news conference.

That France The Prime Minister, Jean Castex, on Friday said the upcoming regional elections scheduled for March should be postponed until June, a day after confirming that the state’s two-week lockdown would not diminish for at least another two weeks.

While the rate of increase continues to slow down significantly, France has the fourth-highest number of confirmed cases in the world, nearly 1.9 million, and the number of people hospitalized with the coronavirus has hit an all-time high of 32,638.

Castex said France could begin loosening restrictions from December 1 provided the number of cases continued to fall, first by allowing nonessential shops to reopen. But bars and restaurants will not be allowed to resume operations until later, he said.

Several European countries including France, Belgium, that Netherlands, that Czech Republic and Ireland has been reported slowing down new infections since introducing strict new measures last month, but hospital services remain under severe stress.

IrelandThe prime minister, Micheál Martin, said on Friday that the country could start a phased approach after December 1, with the aim of easing restrictions ahead of Christmas “because I understand that people will want to meet with families.”.


Elsewhere, however, infections are on the rise. Sweden recorded a record 5,990 new cases on Friday, the highest since the start of the pandemic, the national health agency said, as well as 42 new deaths bringing the total to 6,164.

The Scandinavian country, which has a significantly higher number of COVID-19 deaths per million population than its Nordic neighbors, is battling the second wave health officials are hoping for. light touch, anti-locking approach will reduce.

Russia, which has the fifth-largest number of cases in the world, also reported a record 21,983 infections as Moscow prepares to close restaurants, bars and nightclubs on Friday between 11 p.m. and 6 a.m. to mid-January in a bid to contain the pandemic.

Officials warn of raids and fines for companies that do not comply. The capital has also moved students and university students to online learning and recommended that school children, who are already studying from home, minimize travel.

Outside Europe, the virus is returning to New York City after that it took effect over the summer, with the city’s seven-day positive Covid-19 test average rising to 2.6% on November 11.

The governor, Andrew Cuomo, urged New Yorkers to “do their part” and “take this seriously” as officials begin to cancel some reopens, sparking fears of a more dramatic closure and possible school closings.

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Matrix party ‘disguised as film shoot’ to bypass German Covid rules | World News | Instant News


German health authorities have said they plan to speak to the studio where the latest Matrix film was shot after a party the Hollywood actor allegedly attended. Keanu Reeves held to mark the end of filming, despite coronavirus restrictions.

About 200 people attended the party disguised as filming a film, with guests being invited to come as extras in an apparent attempt to bypass health regulations, according to German tabloid Bild.

Parties of up to 50 people are allowed in Berlin and the neighboring state of Brandenburg, where the party reportedly takes place at the film studios Babelsberg, west of the German capital. But they have to be registered in advance along with the submission of a “clean concept” which must be approved by the authorities. Guests must adhere to distance rules, and wear masks when not eating and drinking.

A 39-year-old female guest at the party told Bild: “The atmosphere is very happy. Everyone is given a PCR corona test first. Everyone has to come wearing a mask but many people don’t wear it during the party. “

He added: “No directing instructions were given, no clapperboards and nothing to record.”

The party, hosted by producers Lana and Lilly Wachowski, is codenamed “Icecream Teamevent” according to the newspaper, citing sources, and starts at 6pm on Wednesday and continues into the early hours of Thursday.

Guests were entertained by dancers, DJs and a fireworks display, and invited to get Matrix tattoo souvenirs. Beverages include sushi, sake, pizza, Currywurst (sausage curry, a Berlin specialty) and vegan chocolate apricot cake. Bedouin-style tents and hippy-style caravans are available for guests wanting more privacy.

Reeves and his partner, artist Alexandra Grant, sit at tables drinking wine, and leave early in the evening, reports Bild.

Bianca Markarewicz, spokeswoman for Studio Babelsberg, said according to franchise producer Matrix, the film team was shooting a “celebratory scene, which was filmed in the summer, and it has something to do with it. Hygiene regulations are followed. “

He added: “The production team consciously did this shoot with a lot of participants, right at the end of filming.”

The German case

A spokesman for the city of Potsdam, who was in charge of granting permission for the parties to proceed, said: “No events have been announced to us. There is ongoing discussion between health authorities and the studio on the topic of infection protection during filming. “

He said health authorities would speak to the studio.

The faintest smell of bad publicity will be the one Reeves has received the most in some time, after becoming a rare, relatively scandal-free Hollywood celebrity. His introverted personality and elegance with fans has earned him the nickname “internet girlfriend”.

Earlier this year, he helped organize a van after a flight he was on in California got stranded, and was filmed reading aloud to passengers on the way. Actor Octavia Spencer also said he once helped push his car when it broke down. “What Would Keanu Reeves Do?” is a popular slogan on unofficial merchandise.

Reeves also won praise for having an “age-appropriate relationship” after it was revealed that the actor, 56, is dating Grant, who is 47.

Filming in Matrix 4 was interrupted in March due to the coronavirus pandemic but resumed in Berlin in August. It is scheduled for release in December 2021.

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Mapping for predicting tick distribution in Switzerland | Instant News


A comprehensive study by EPFL and the University Hospital of Lausanne (CHUV) has enabled researchers to map the geographic distribution of ticks in Switzerland for the first time, as well as to determine whether they are carriers of chlamydia. Little is known about these bacteria, but fleas have the potential to transmit them to humans. The team found that the zone conducive to tick proliferation had grown by 10% over the past decade.

Pedestrians departing on one of the many walking trails in Switzerland often bring back beautiful photos, the occasional cramp, and – accidentally – fleas. These tiny akarids, which are in dense bush and on the edges of forests, are very active in hot weather and cling to human and animal hosts passing nearby. Despite their small size, they can transmit potentially serious diseases such as Lyme disease and tick-borne encephalitis. Recent research by the Institute of Microbiology at CHUV has shown that fleas are often carriers of large amounts of chlamydia, a still poorly understood bacteria that can be transmitted to humans and cause secondary disease.

Scientists recognize that tick breeding and activity are influenced by a variety of environmental factors, including temperature and humidity. However, data on its regional distribution over time in Switzerland are lacking, which has been classified as a risk area. At EPFL’s Geographical Information Systems (LASIG) Laboratory, Estelle Rochat’s thesis project aims to address this void and identify areas where ticks carry chlamydia. His extensive mapping work has been published at prestigious events Applied and Environmental Microbiology.

Three data sources

After identifying the environmental conditions conducive to the presence of castor bean infestation (Ixodes ricinus), the most common species of tick in Switzerland, Rochat created a map of their geographic distribution between 2008 and 2018.He drew on three databases: a 2009 field campaign carried out by the Swiss Army , where more than 60,000 ticks were collected and analyzed; thousands of entries to smartphone application which allows the user to indicate where they are observing ticks; and a Rochat-led flea collection project in 2018.

He then used machine learning (a form of artificial intelligence) to predict the possible presence of ticks and bacteria based on values ​​taken from a set of environmental data (rainfall, temperature, humidity, etc.) around the collection point.

© LASIG

The machine learning program allowed Rochat to estimate the location of the ticks, and revealed that the surface area of ​​the zone favorable for tick propagation grew from 16% of mainland Switzerland in 2008 to 25% in 2018.

Statistically, the model works well. Using the rule of probability, we can find out whether a particular location is tick friendly, or if, conversely, ticks are unlikely. Using a distribution model, we estimated the prevalence of bacteria within these sites. This in turn allowed us to identify subzones where favorable areas for ticks also support chlamydia.

“A landmark project”

The scope, originality and novel approach of Rochat’s research won praise from Gilbert Greub, a world-renowned chlamydia and lice expert and director of the CHUV Institute of Microbiology. “This is an important project, and contains enough detail at the national level to allow us to draw conclusions. We can clearly see that between 2008 and 2018, there was an increase in the area of ​​high risk tick exposure, which in my opinion is a reflection of global warming. This indicates that the ticks have migrated 300-400 meters higher in the subalpine zone. “

For Greub, the study is a valuable tool for preventive purposes, as well as for awareness raising. In addition, it will be useful at the Institute, which conducts clinical studies of the impact of tick-borne chlamydia on humans.

The Rochat model is now available in open access and could be used in future research on tick-borne pathogens. “It’s interesting to see how the ecological niches overlap. We use chlamydia in this case because we are working with Gilbert Greub, a global expert, but our approach can also be applied to tick-borne encephalitis and Lyme disease. The algorithms needed to process environmental data are available free of charge and can be applied to other data sets, ”said Stéphane Joost, who supervised Rochat’s thesis at LASIG.

Joost sees an opportunity for the Swiss Federal Public Health Office to refine its risk map for head lice – which will be increasingly present in Switzerland as a result of global warming.

More fleas? Keep calm.

According to Gilbert Greub, Director of the CHUV Institute of Microbiology, the presence of more ticks in a particular zone increases the chances of being exposed to certain diseases. Over the past three years, patient consultations for tick bites, Lyme disease and tick-borne encephalitis has increased. Greub reiterated the recommendations of the Swiss Federal Public Health Office. “Summer is very beautiful here and people love cycling and walking. The most important thing is to get vaccinated against tick-borne encephalitis. Second, avoid hiking in remote high-risk areas – or if so, wear trousers that tuck into your socks. In addition, you should check yourself closely at night when you return from the climb, including your back and other hidden areas. No need to panic or check every half hour. However, if you find a check mark, use the check mark brace to remove it. “

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