Tag Archives: Muscle

The puppet regime is incapable of running the country, the economy | Instant News

KARACHI: The second public meeting of the Pakistan Democratic Movement (PDM) will be held in Karachi on Sunday (today). The Pakistan People’s Party is holding a public meeting in Bagh-e-Jinnah near the tomb of Quaid-e-Azam Mohammad Ali Jinnah.

The central leadership of the opposition alliance will address the public meeting. They include JUI-F chairman Maulana Fazlur Rehman, PPP Chairman Bilawal Bhutto Zardari, PML-N Vice President Maryam Nawaz, former prime minister Shahid Khaqan Abbasi, Ahsan Iqbal, Maulana Shah Owais Noorani, Allama Sajid Mir, Dr Abdul Malik, Iftikhar Hussain, Ameer Haider Khan Hoti, Dr Jehanzeb Jamaldini and others. Fazlur Rehman has arrived in the city while PML-N Maryam Nawaz will reach the city today (Sunday).

PPP chairman Najmi Alam said 50,000 seats were placed in Bagh-e-Jinnah for rally participants. Flags of all components of the PDM political parties and welcoming banners for their political leaders were also displayed at the venue. Special arrangements for lighting and sound systems have also been made at the venue. About 1,500 workers from the People’s Party volunteers will regulate traffic movements and ensure that participants pay close attention to anti-coronavirus precautions. The public meeting will start at 16.30. There will be special security arrangements for public gatherings. Different routes have been established for different political party processions to reach the venue. PPP Chairman Bilawal Bhutto Zardari together with Chief Minister Sindh Syed Murad Ali Shah and Minister of Education and Manpower Sindh Saeed Ghani visited the venue for the public meeting. The PPP chairman received an explanation regarding the arrangement and preparation for the public meeting.

Speaking to reporters on the occasion, the PPP chairman said that the PPP will hold a historic public meeting and October 18 will be an unforgettable day in Pakistan’s history. He said the parliament and judiciary were not free and the PDM had decided to continue their struggle until the restoration of democracy.

Bilawal said that the elected government was unable to run the economy and the country. He said that the PDM’s first public meeting in Gujranwala had sent a clear message that the masses were not willing to let Imran Khan go so easily because he had made people’s lives miserable. He said that the elected prime minister had robbed the people of inflation and shortages of wheat and sugar. He said we were not looking towards ‘Umpire’ but witnessing the plight of people whose mandates were robbed and their fate handed over to “incompetent elected leaders.” He said the federal government rejected Sindh’s supposed share in the NFC Award and refused funding for the Karachi upgrade. Bilawal said the “elected prime minister and his facilitators” would be held accountable for these crimes. Referring to PIDA regulations, he said the federal government was trying to take over the islands of Sindh and Balochistan under construction suits.

Responding to the prime minister’s remarks on the judiciary, Bilawal said the prime minister thought he could run the judiciary like his Tiger Force. The people want justice without discrimination and want to hear the judge’s decision on Aleema Baji and the accountability of K Electric, which is run by the Abraj Group, which is the main sponsor of PTI. He said we wanted indiscriminate action against corruption be it by courts or generals.

The PPP chairman said the chairman of the National Assembly was also part of the puppet regime and he and the prime minister should be sent home. He said by refusing a production order, the speaker turned down Opposition Leader Shahbaz Sharif, the opportunity to speak at the National Assembly which is his constitutional right.

Meanwhile, Bilawal said his struggle for the restoration of democracy, the supremacy of the constitution and an elected parliament, the protection of the people’s human rights will continue despite the threat of the “elected prime minister”. “It is time to end the self-centered selector game and elect and empower (the people) and elected (people’s representatives) voters to save the country and its people from further calamities,” he said while paying shining tribute to the martyrs of the ‘Massacre. Karsaz ‘when a public demonstration welcoming Shaheed Mohtarma Benazir Bhutto on his return from exile was bombed which resulted in the death of 180 PPP workers and injuring more than 500 others, 13 years ago in Karachi.

Bilawal said all democratic political parties and their leadership will gather in Karachi today (Sunday) to pay tribute to their highest sacrifice in giving lives for democratic causes during the battle against the dictatorship.

The chairman of the PPP said the Pakistan Democratic Movement (PDM) was an alliance of all democratic political parties that came together to get rid of all crimes linked to the destruction of democracy, economy and foreign policy. He said his party workers embraced martyrdom for the restoration of democracy, the supremacy of the constitution and an elected Parliament, the protection of the basic human rights of the masses. The struggle is still continuing despite the umpteenth sacrifice of victims of terrorist attacks, fake cases, arbitrary arrests and now facing open threats from the elected prime minister, he added.

Earlier, Sindh government spokesman Barrister Murtaza Wahab declared that the Pakistan Democratic Movement rally in Karachi would become a public referendum, saying the 22 crore case of Pakistanis would be fought on the streets.

In a press conference, Wahab said Pakistanis in their right mind would announce their decision against the regime on Sunday (today). Labor and the poor are exploited, unemployment rises in countries and people are crushed by inflation.

PPP Co chairman Asif Ali Zardari is not worried about the cases that happened to him in the past, nor will he be depressed now. The PDM struggle continues for the survival of democracy, he said, adding that Sheikh Rashid’s remarks should not be taken seriously which should pay more attention to railways which have gone from bad to worse in the last two years.

Separately, Saeed Ghani said that the popularity of the People’s Party is on the rise as former legislators from various political parties joined the PPP and the trend will continue. He said that with this trend, the PPP would be further strengthened and the next elected Karachi mayor would be from his party.

He said that the People’s Party would host a bigger public PDM meeting in Karachi (today) than in Gujranwala. He said the PDM’s second public meeting would further disappoint the PTI federal government which had failed to provide assistance to the masses. Ghani said that Bilawal Bhutto Zardari on Friday chaired a massive rally from Lalamusa to Gujranwala which proved that PPP is very much alive in Punjab.

On this occasion, the Sindh Information Minister and the Regional Government Syed Nasir Hussain Shah said that politicians from other political parties who are members of the People’s Party showed that PPP was very popular among the masses.

PPP Secretary General Sindh Waqar Mehdi said that provincial ministers and PPP parliamentarians in Sindh would not hesitate to resign from their posts in line with a PDM decision whenever the party leadership asked them to do so. But it is likely that the rulers will step down before December this year and the need for resignation has never arisen.


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Heart enlargement related to autoimmunity is associated with the risk of heart failure in type 1 diabetes | Instant News

People with type 1 diabetes, especially those with poor glycemic control, are at a very increased risk for cardiovascular disease than the general population. Even more confusing, in individuals with type 1 diabetes, many cardiovascular risk factors are not in line with known risk factors associated with type 2 diabetes.

Dr. Myra Lipes, Investigator in the Immunobiology Section at the Joslin Diabetes Center at Harvard Medical School, has worked for more than a decade to understand what causes an increased risk of cardiovascular disease in patients with type 1 diabetes and what can be done about that.

Heart failure in particular has recently been recognized as an important type 1 complication with a national register-based study that shows a tenfold increase in the risk of heart failure in individuals with poor glycemic control. In addition, there is a higher case fatality rate in type 1 diabetes than in type 2 diabetes, which suggests different mechanisms for heart failure might be involved in type 1 diabetes.

Myra Lipes, Investigator in the Immunobiology Section at the Joslin Diabetes Center at Harvard Medical School

Given the burden of heart failure in type 1 diabetes, early identification of patients with certain risks is very important.

New research from Dr.’s lab Lipes in Joslin showed that in people with type 1 diabetes without known cardiovascular disease, the presence of autoantibodies to cardiac muscle protein is associated with evidence of cardiac magnetic resonance imaging (CMR) that shows an increase in left ventricular volume (the main heart pumping chamber), increased muscle mass and reduced pumping function (ejection fraction), a feature associated with a higher risk of failure in the general population. This new study was published in Circulation.

Antibodies are usually produced by the immune system and circulate in the blood, playing an important role in the body’s defense against infection. In people who tend to be autoimmune, the body misidentifies its own protein as a threat and attack. This is what happens with type 1 diabetes – the immune system thinks the pancreatic beta cells are the invaders and destroy them. In this situation, antibodies are called autoantibodies. So, it might not be too surprising that this type 1 diabetes complication also involves an incorrect immune response to heart muscle cells.

Previous studies conducted by Dr. Lipes has shown that a mouse model of type 1 diabetes develops dilated cardiomyopathy (weakened heart muscle) and premature heart failure associated with the presence of autoantibodies directed against cardiac muscle protein. His group also showed that poor glycemic control in patients with type 1 diabetes – but not in those with type 2 diabetes – was associated with cardiac autoimmunity. Unexpected findings are similar rates of cardiac autoantibodies in patients with type 1 diabetes, who are young and without diabetes complications, and a cohort of heart failure with Chagas cardiomyopathy, which is thought to be caused by chronic inflammation of the heart muscle (“myocarditis”), increasing the likelihood of dysfunction myocardial associated subclinical autoimmune in type 1 diabetes “said Dr. Lipes.

In this study, Lipes wanted to determine whether the widening cardiac phenotype seen in mouse models and Chagas patients was also present in people with type 1 diabetes who have this circulating autoantibody. He and his team used data collected from participants involved in the Diabetes Control and Complications (DCCT) study post-Diabetes Epidemiology Intervention and Complications (EDIC) follow-up studies, and consisted of people who had type 1 diabetes for an average of 28 year. As part of this study, participants were imaged with CMR, a gold standard noninvasive imaging technique to assess the structure and function of the heart.

“In this study, we measured autoantibodies against cardiac muscle protein in blood samples taken from CMR imaging in 892 EDIC participants without known cardiovascular disease,” Lipes said. “And then we examined where the presence of heart antibodies was associated with CMR evidence of myocardial dysfunction.”

They found that although recent A1c levels were similar in participants with and without cardiac autoantibodies, the presence of cardiac autoantibodies identified patients with worse glycemic control in the past, indicating that cardiac autoantibodies were a marker of long-term glycemic exposure. In addition, they found that CMR scanning of people with two or more autoantibodies showed an enlarged heart. They sorted patients into categories based on the number of circulating autoantibodies, which indicates that people with more of these specific autoantibodies have clearer changes in the heart. This finding did not weaken after adjusting for traditional cardiovascular risk factors, suggesting this change was mainly due to cardiac autoimmunity.

They know from previous research that the heart can have structural and functional changes related to the metabolic problems of diabetes itself; However, this relationship is relatively simple. For example, higher A1C levels are associated with slightly smaller left ventricular volume that is not clinically significant. But this research shows that higher A1C levels can trigger additional autoimmune responses that damage the heart in different and clearer ways that lead to enlargement and worse function, features that are known to be associated with a higher risk of heart failure.

“This points to a new process that involves the heart and is associated with poor glycemic control in type 1 diabetes,” Lipes said.

Because cardiac autoantibodies can be detected in a simple blood test, this study opens new avenues for detecting potential heart failure in patients with type 1 diabetes.

“Given the high burden of heart failure in type 1 diabetes, heart antibodies can allow early identification of people at higher risk of heart failure,” Lipes said. “And, of course, understanding the main causes of heart failure is important because it can lead to therapeutic approaches that are targeted at improving outcomes in these patients.”


Journal reference:

Sousa, G.R., et al. (2020) Cardiac Immunity Associated with Subclinical Myocardial Dysfunction in Type 1 Diabetes Mellitus Patients. Circulation. doi.org/10.1161/CIRCULATIONAHA.119.044539.


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