Tag Archives: national

Preparatory roundup: Lady Hurricanes claims the 5-AAA title in dramatic fashion | Instant News

With the District 5-AAA regular season championship – and the top seed for the district tournament – at stake, East Hamilton and Soddy-Daisy needed two additional innings to determine a winner.

After a goalless play into the ninth half, Lady Trojans pushed a lap at the top of the inning, but East Hamilton answered at home with a two-run home run by Syerra Rogers for a dramatic 2-1 win.

Rogers also won the ball, spread five strokes and scored 16 goals for Lady Hurricanes (20-6-1, 11-1), who managed just two shots from Lady Trojans starter Taylor Lloyd, who scored 13 goals.

Hope Ingle made three hits for Soddy-Daisy and Makayla Perez also had a pair of hits.

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East Hamilton vs. Soddy-Daisy


* Whitwell 5, Grace Academy 4: Senior leadoff hitter Trevor Davenport scored a goal tying the game to midfield in the 12th inning and Dakota Morrison followed up with an RBI walkoff for a home win – a regular season final that took four hours to complete.

“This win put us all together. It was not easy, but we got the job done in the end,” said Davenport. “This win will definitely stick with me. So many different men did their job and winning our last home game meant a lot to me.”

Morrison and Hunter Cookston both had three strokes for the Tigers who took their punches throughout the game. Senior Zach Scissom grabbed the win in release while Cole Burns stood out with two strokes and RBI.

“Entering this year are only five players on the team who have university baseball experience,” said coach Whitwell Heath Thacker. “They all came together tonight and found a way to fight and get this victory. It was an extraordinary moment for many of our people. The results of their hard work paid off tonight.”

Grace Baptist starter Caleb Adams had a strong eight innings and scored eight strokes and also hit a home run in the park to take a 4-3 lead in the 12th inning. Noah Bastian also stands out on the pitch and on top of the Golden Eagle mound.

* Marion County 9, Sale Creek 7: Nathan Hoback scored three shots for the Warriors while Bryce Weeks went on four. Jakob Elrod scored three strokes for the Panthers, who allowed four expensive strokes in the second and fourth innings.

* Bradley Central 7, McCallie 1: Dakota Peace and Cooper Casteel had two hits apiece while Daniel Cox rode in a pair of runs for the Bears. Casteel grabbed the win on the mound which allowed one round in three innings. Kyle Berry went 2-for-4 with the RBI for McCallie.

* Notre Dame 2, CCS 0: David Brownlee scored two strokes while Mith Grannan raced through for the Irish and also scored three strokes. Ryan Eiselstein also threw a 3 1/3 innings shutout at releif for Fighting Irish. Cole Headrick went 2-for-4 for CCS.


* Silverdale Baptist 14, CCS 1: Emry Masterson, McCade Cooper and Bentlee Stiner all progressed in three rounds while Katie Willoughby scored eight of five one-shot ball innings.

* GPS 8, Boyd Buchanan 7: The Bruisers scored six points in the third set to help make the difference as McKamey Bratcher and Emily Leinberger tripled each. Boyd Buchanan had six additional basic strokes while Izzy Messer went on three strokes and homer along with Presley Williamson.


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How to avoid travel scams | Instant News

Q. We are looking for airline tickets for a summer vacation. What advice can BBB provide? A. With the rollout of COVID-19 vaccines, travel is coming back. This is great news for summer vacation plans … and scammers. BBB Scam Tracker, bbb.org/scamtracker, receives reports of scammers creating fake airline ticket booking sites or customer service numbers. If you are buying an airline ticket, be careful and verify the URL or phone number before providing your credit card information. How The Scam Works By searching online for cheap flights, you come across what appears to be a good deal with a major airline. You book the flight – either through the website or by calling a customer support number – and receive a confirmation message. However, when you take a closer look at the email, you notice that you never received your ticket. In another version of this scam, you book a flight through a travel website that offers deals on airline tickets. You pay with your credit card as usual. But shortly after you make the payment, you get a call from the company that there was a sudden price increase or additional charge to finalize your reservation. This is something a legitimate business would never do! Either way, you call the airline to track your flight. After talking to an agent, you find that they have no record of your reservation. It turns out that you accidentally bought tickets through a scam website or fake customer service number. A victim told BBB Scam Tracker: “I got a phone call right after [I booked the flight] stating that they wanted $ 100 per passenger to finalize my flight. Then, after calling the airline to complain, the victim discovered that “the flight was not available initially. The flight was never booked … this company just debited my card. “How To Avoid Travel Scams Do Your Research. If you come across a company that you’ve never dealt with before, research them before you make any purchases. Look at BBB.org for reviews and comments from previous customers . Check the URL before entering your personal and payment information. It can be easy to click on a sponsored ad or impostor website without realizing it. Before entering sensitive information, make sure you are on the correct one website and the link is secure. (Secure links begin with “https: //” and include a padlock icon on the purchase page. Learn more at BBB.org/BBBSecure.) Beware of sites Third Party Web. Some Websites seem to offer a legitimate service, but are just scam facades. Beware of websites without a working customer service number and physical address. Typos and gramma errors ticals can also indicate the work of a con artist. Shop online with your credit card. F Exorbitant charges made on a credit card can usually be disputed, while it may not be with other payment methods. Unfortunately, there is no way to retrieve the personal information you have shared. For more on planning a getaway during COVID-19, check out this tip from BBB. For more information on how to protect yourself from travel scams, visit BBB.org/TravelScam. Learn more about scams at customer service number bbb.org/article. If you have been the victim of a plane ticket or other travel scam, please report your experience to BBB.org/ScamTracker. By doing this, you can help others avoid falling prey to con artists. Jim Winset is president of the Better Business Bureau in Chattanooga. .

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New Zealand Scores Well in Anti-Money Laundering, but Gaps Remain, Watchers said | Instant News

New Zealand has put in place some effective measures to combat money laundering and terrorist financing, but there are still gaps to be overcome, according to a report from the international standards body.

The Financial Action Task Force, a Paris-based organization that also monitors legislation aimed at fighting money laundering and terror financing, said New Zealand’s measures were “yielding good results,” but the country needed to increase transparency of beneficial ownership information. , strengthen sector-specific surveillance reporting suspicious activity and better monitor compliance with financial sanctions to prevent terrorist financing, according to an evaluation published on Thursday. The country was last evaluated by the FATF in 2009, with a follow-up in 2013.

A representative from the New Zealand Department of Home Affairs, which is the body responsible for overseeing compliance with anti-money laundering and terrorism financing regulations, was not immediately available for comment.

“The report recommends increasing the scope and depth of the Reserve Bank [Anti-Money Laundering/Combating the Financing of Terrorism] banking sector oversight, ”a spokesman for the Reserve Bank of New Zealand, another watchdog, said in a statement. “To the extent possible, the Bank is addressing this within the scope of the five-year funding agreement approved last year.”

The FATF lauds many aspects of New Zealand’s anti-money laundering and anti-terrorist financing system. The country’s law enforcement agencies regularly use financial intelligence to detect potential criminal activity and investigate and prosecute offenses, particularly in recovering the proceeds of crime, according to the report.

The group said New Zealand also needs to strengthen oversight of certain sectors, including lawyers, accountants and real estate agents, which have been included in the scope of the country’s anti-money laundering measures in recent years and must now put in place processes and systems. to deal with money laundering and terrorism financing.

More From Risk & Compliance

The FATF recommends that New Zealand increase the transparency and availability of accurate and up-to-date beneficial ownership information, such as limited liability companies and partnerships, which can be used to launder illicit funds, after implementing measures to reduce risks associated with companies and limited liability companies. partnerships in recent years.

New Zealand law enforcement also remains wary of funds being used for domestic terrorist attacks in the aftermath mass shootings at two mosques in Christchurch in 2019, said the FATF. Terrorist financing investigations have also been thorough and well-coordinated, the group said in the report.

New Zealand has a strong legislative framework for implementing financial sanctions to combat terrorist financing, such as asset freezes, said the FATF. But the report notes that there are no assets frozen in New Zealand under its financial sanctions regime, which may be consistent with the country’s risk profile.

The FATF also found that some New Zealand entities have different understandings of sanction compliance obligations, due to limited guidance from the authorities and a lack of a mandate for regulators to enforce these requirements.

Write to Mengqi Sun at [email protected]

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Vifor Pharma and Angion announce completion of enrollment in phase-II study ANG-3777 for cardiac surgery-related acute kidney injury | Your money | Instant News

ST. GALLEN, Switzerland & UNIONDALE, NY – (BUSINESS WIRE) – 29 Apr 2021–

Regulatory News:

This press release features multimedia. Check out the full release here: https://www.businesswire.com/news/home/20210428005922/en/

Vifor Pharma and Angion Biomedica Corp. (NASDAQ: ANGN), today announced the completion of enrollment for the AKI-002-15 Angion study, the ANG-3777 phase-II trial in patients at risk for acute kidney injury (CSA) related to heart surgery. -BATTERY). This indication is part of the ANG-3777 license agreement signed by the two parties in November 2020.

“CSA-AKI is a frequent complication of heart bypass surgery that occurs in about one-third of patients and is associated with prolonged hospitalization, progressive renal failure, and an increased risk of death,” commented Dr. John Neylan, Senior Vice President and Chief Medical Officer Angion. “At this time, there is no approved therapy to prevent this serious condition. This phase-II preventive trial was designed to generate data on ANG-3777 in CSA-AKI patients to help guide future ANG-3777 development in a phase-III registration trial for CSA-AKI. We plan to begin confirmatory trials as early as 2022, subject to the results of this phase-II trial as well as discussions with the FDA and other relevant health authorities. “

Klaus Henning Jensen, Chief Medical Officer of Vifor Pharma Group commented: “We are very pleased that registration for the AKI-002-15 phase-II trial has been completed. This is an important milestone in a comprehensive clinical program to advance ANG-3777 as a potential treatment option for preventing acute kidney injury following cardiac surgery, an indication with an unmet medical need. Together with our partner Angion, we now look forward to assessing the results of the trial. “

Fully enrolled Phase-II trials are randomized, multi-center, double-blind, placebo-controlled clinical trials with trial sites in the United States, Canada, Brazil, and Georgia. Patients at risk for CSA-AKI were randomized one-to-one to receive four intravenous doses of 2.0 mg / kg ANG-3777 or placebo over four days. The first dose is given within four hours after the operation is over with subsequent doses given at 24 hour intervals. The primary endpoint was the mean area under the curve of the percentage increase in serum creatinine above baseline, starting 24 hours after the end of cardiopulmonary bypass surgery to the sixth day. An additional important end point is the occurrence of a Major Adverse Kidney Event at 90 days (MAKE 90), which has previously been approved by the FDA as a suitable primary endpoint for registration trials in this indication. The MAKE 90 “event” was death, initiation of renal replacement therapy or a decrease in eGFR of more than 25% that occurred 90 days after surgery. The AKI-002-15 phase-II trial was designed as a strategic-purpose signaling test to obtain sufficient evidence of the efficacy of ANG-3777 to provide proper strength and evaluate potential enrichment strategies for phase-III registration trials.

About ANG-3777

ANG-3777 is an investigative small molecule designed to mimic the biological activity of hepatocyte growth factor (HGF), which activates the c-Met cascade of pathways involved in tissue and organ repair. ANG-3777 has demonstrated a significantly longer half-life than HGF and Angion believes ANG-3777 has the potential to be a first-class therapy for acute organ injury. Enrollment was completed in a phase-III registration trial in transplant-related acute kidney injury, also known as delayed graft function, a phase II exploratory trial in cardiac surgery-related acute kidney injury, and a phase II exploratory trial in patients with associated acute lung injury. with COVID-19 pneumonia. In November 2020, Vifor Pharma and Angion signed a licensing agreement for global rights excluding Greater China to commercialize ANG-3777 in kidney indications with up to $ 1.925 billion in development, commercial and sales achievements plus royalties on net sales of up to 40%. Sinovant Sciences and Angion signed a development and licensing agreement for ANG-3777 in Greater China in 2018.

About Vifor Pharma Group

Vifor Pharma Group is a global pharmaceutical company. It aims to become a global leader in iron deficiency, nephrology and cardiovascular therapy. The company is the partner of choice for innovative patient-focused medicines and solutions. Vifor Pharma Group strives to help patients around the world with severe and chronic diseases lead better and healthier lives. The company develops, manufactures and markets pharmaceutical products for precision patient care. Vifor Pharma Group holds a leading position in all of its core business activities and consists of the following companies: Vifor Pharma and Vifor Fresenius Medical Care Renal Pharma (a joint venture with Fresenius Medical Care). Vifor Pharma Group is headquartered in Switzerland, and is listed on the Swiss Stock Exchange (SIX Swiss Exchange, VIFN, ISIN: CH0364749348).

For more information, please visit viforpharma.com.

About Angion

Angion is committed to changing the treatment paradigm for patients suffering from acute organ injury and fibrotic disease for whom no approved drug or approved drug has restrictions. Angion’s main product candidate, ANG-3777, is mimetic hepatocyte growth factor (HGF) which is currently being evaluated in a Phase 3 registration trial for delayed graft function in patients undergoing transplantation of a deceased donor kidney, Phase 2 trial on cardiac surgery associated acute kidney injury, and a Phase 2 trial in patients with COVID-19-associated pneumonia at high risk for acute respiratory distress syndrome. Angion is currently also evaluating ANG-3070, a tyrosine kinase receptor inhibitor for the treatment of fibrotic disease, in Phase 1. Additionally, Angion has preclinical programs for rho kinase 2 (ROCK2) inhibitors and CYP11B2 (aldosterone synthase) inhibitors. For more information, please visit www.angion.com.

Angion Forward Looking Statement

The statements contained in this press release regarding matters that may occur in the future are “forward-looking statements” in the meaning of the Private Securities Litigation Reform Act of 1995, including but not limited to statements in this press release regarding Angion’s expectations regarding potential for safety. and the efficacy of ANG-3777, potential outcomes and results of the AKI-002-15 study, and other studies involving ANG-3777 or other candidate products, future clinical trial initiation times and availability and Angion’s disclosure of topline data from those studies. Such statements are subject to risks and uncertainties and actual results may differ materially from those expressed or implied by those forward-looking statements. In particular, the following factors, among others, could cause the results to differ materially from those expressed or implied by such forward-looking statements: Angion’s ability to demonstrate sufficient evidence of efficacy and safety in clinical trials of ANG-3777 and other products. candidate; the accuracy of Angion’s estimate with respect to its ability to initiate and / or complete clinical trials; the results of preclinical studies may not predict future outcomes; unpredictable regulatory processes; regulatory developments in the United States, and other foreign countries; clinical trial costs may exceed expectations; Angion’s ability to raise additional capital; effect of COVID-19 on Angion’s clinical programs and business operations. For a description of the risks and uncertainties that could cause actual results to differ from those disclosed in the forward-looking statements, see Angion’s Annual Report on Form 10-K for the year ended 31 December 2020, filed with the Securities and Exchange Commission in March. 30, 2021, as well as other documents that Angion may submit from time to time to the Securities and Exchange Commission. Investors are cautioned against relying too heavily on these forward-looking statements, which only take effect as of this release date. Angion is under no obligation to update any forward-looking statements in this press release, except as required by law.

See the source version at businesswire.com:https://www.businesswire.com/news/home/20210428005922/en/

CONTACT: Media Relations

Nathalie Ponnier

Head of Global Corporate Communications

+41 79 957 96 73

[email protected]

Investor Relations

Julien Vignot

Head of Investor Relations

+41 58 851 66 90

[email protected]

For Angion:

Daniel Ferry

LifeSci Advisors


[email protected]



SOURCE: Vifor Pharma

Business Wire Copyright 2021.

PUB: 04/29/2021 01:00 AM / DISC: 04/29/2021 01:00 AM


Business Wire Copyright 2021.


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New Zealand Travel: Why I was wrong about a guided tour | Instant News


A view on the majestic Routeburn Track, one of New Zealand’s Great Walks. Photo / Michelle Langstone

Be surrounded by beauty in Fiordland National Park, Michelle Langstone have a change of heart

I am 42 years old and I have never been on a guided travel tour. It is worth mentioning this as I am a bit of a group phobia and organized schedules. I don’t like to do things at the same time as everyone else, and I’ve always viewed onward travel as a kind of hell you can’t leave – getting into a bus or boat with a stranger, it can’t be said in your own destiny, has to get on go down and dutifully record your attendance at famous places. I want to state for the record that I was very wrong, and provide evidence of, a truly delightful one-day tour of Fiordland National Park.

My husband and I were picked up early in the morning from Te Anau by a very friendly man named Ross, from Trips and Tramps, a local tour company. We boarded the comfortable bus and gathered the rest of our group, then set off for Milford Sound, for a day that promised a little bit of everything – great views, some wildlife, the sound of its own, and the chance to hike several Routeburn trails.

Our coach doubles as the NZ Post van, and our guide stopped at a local butcher to pick up meat and other packages to be shipped further along during our trip, which was both interesting and very practical. We lost cell phone reception about 20 minutes after driving inland, and handed our shiny screen lights over to the silvery beech trunks of the forest we passed. That’s when I realized how much fun it is to drive through the landscape, once your itinerary is mapped out for you – it means you can really enjoy the experience, not worrying about roads or gas gauges.

Kotuku - a rare white stork - on a wharf in Milford Sound.  Photo / Michelle Langstone
Kotuku – a rare white stork – on a wharf in Milford Sound. Photo / Michelle Langstone

I have never felt so relaxed in centuries, and Ross’s incredibly informative talk is the perfect companion to an environment that seems to deepen the beauty of every kilometer – Eglinton Plains in its shimmering expanse, calm, cool Lake Mirror on gray mornings, and kilometers. after kilometers of dark green moss and moss-filled rainforest. At every stop we make to walk and spy on beauties, I breathe clean air and feel grateful.

Tours are also great for collective fun shared as you witness the beautiful things. The first time I saw a kea glint through the trees, the ruby ​​under her wings gave it away, there was a cry of joy and it brought us all together. I’ve never seen kea in the wild, and I’m not shy to say I got a little teary.

The Milford Sound cruise is part of a Fiordland day trip with Trips and Tramps.  Photo / Michelle Langstone
The Milford Sound cruise is part of a Fiordland day trip with Trips and Tramps. Photo / Michelle Langstone

When we arrived at Milford Sound and stood on the dock near the fluffy white kōtuku, the day was clear, the view into the sound was clear, and the grin on the faces of fellow passengers would melt even a hardened bastard.

We went on a two-hour cruise, something I haven’t done since I was a kid, and I’ve forgotten its primordial majesty – it feels like you’re in a lost world. Even though we missed the dolphins, we saw lots of seals falling on the rocks, bathing in the sun. We sank the boat under a waterfall, and headed out to see the Tasman Sea, mocking our lunch as we headed back to the harbor.

Seeing the mountains reflected in the smudges at the top of Key Summi on the Routeburn Track is simply amazing.  Photo / Michelle Langstone
Seeing the mountains reflected in the smudges at the top of Key Summi on the Routeburn Track is simply amazing. Photo / Michelle Langstone

The final part of the tour is what I look forward to the most – the chance to walk a few hours on the legendary Routeburn track. Our guides give us the option of taming, guided walking, or getting down on our own for a few hours, and we’ve chosen the latter. Routeburn holds a special place in my heart – there is a legend in my family about how Dad took Mom on a walk to winter in Routeburn, and then proposed to her a week later, impressed by his fortitude.

Key Summit is one end of Routeburn, accessed in The Divide, and about 2.5 hours drive back up steep terrain, through glowing green forest that opens up to panoramic mountain views. I will never be able to forget the health of Fiordland’s rivers and creeks, and filling my water bottle with clean, freezing water that flows down the mountainside is a joy to me. The bush is spectacular, and the views make a sweaty hike worthwhile every time – seeing the mountains reflected in the smudges at the top of Key Summit is simply awe-inspiring. Getting on the comfortable bus for a warm ride back to Te Anau feels like luxury, and I wouldn’t hesitate to book again.


Trips and Tramps offers half-day, full and multi-day tours around the Fiordland region. tripsandtramps.co.nz


For more New Zealand travel ideas and inspiration, visit newfinder.co.nz and newzealand.com


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