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Corona virus pandemic: Germany warns against traveling to ski areas in Austria, Switzerland, Italy – travel | Instant News


Germany has issued travel warnings for popular ski areas in Austria, Italy and Switzerland, struggling to contain the spread of the virus corona virus as the rate of new infections rose above 10,000 a day for the first time. While the infection rates in Germany are lower than in much of Europe, they are steadily increasing, with a daily increase of 11,287 cases bringing the total to 392,049. The German death toll stood at 9,905. “The situation has become very serious overall,” Lothar Wieler, head of the Robert Koch Institute (RKI) for infectious diseases, said.

“We still have a chance to slow the spread of the pandemic,” he said. But he said people should stick to the rules and that Germany must prepare for an uncontrolled spread of the virus. On Wednesday, German Health Minister Jens Spahn became the latest leading politician to test positive for the virus. His spokesman said he had cold symptoms but had no fever. Government sources said he was fit for work. Berlin issued new travel warnings for Switzerland, Ireland, Poland, much of Austria and parts of Italy including the popular South Tyrol ski area.

The UK, with the exception of the Channel Islands, Isle of Man and overseas territories, is also seen as a high risk region. Under the warning, which takes effect from Saturday, travelers returning to Germany must be quarantined for 10 days. Quarantine can be lifted early, if tests carried out after five days turn out to be negative. The surge in Germany also prompted the Danish government to warn its citizens against traveling to and from Germany, except for the border state of Schleswig Holstein.

Germany’s move could have a significant impact on ski seasons in the Alpine countries. Especially Austria, which reported a record 2,435 new daily infections on Thursday, is a popular destination for Germans. Swiss Tourism spokesman Markus Berger said the news from Germany was definitely not good. The industry hopes that the situation will improve in the next month or two. “We assume that winter can continue,” he said. However, there is positive news for Spain’s Canary Islands as the RKI removed them from its risk list, raising hopes for German tourists over Christmas and New Year.

(This story has been published from a wire agency feed with no modifications to the text. Only the title has been changed.)

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Faces meet fashion in a selection of New Yorkers’ masks in the midst of the coronavirus pandemic – fashions and trends | Instant News


New Yorkers are increasingly embracing the use of masks to slow its spread corona virus since the pandemic started earlier this year. With no end in sight, many have gone beyond standard surgical masks and are choosing to express themselves with more fashionable colors, patterns, flags and messages. Children arrive on the first day of school wearing masks with hearts, books, watermelons and musical notes written on them. A school assistant has a line of crayons on her mask, a friendly design for nervous kindergarten kids. On Madison Avenue, a woman wearing a matching designer mask and scarf walks quickly past an upscale clothing store. And behind it, there is another mask with a skull.

In Harlem, Hana Teferi walked out of a shop wearing a gold, black and silver Ethiopian mask which she wore in honor of her Ethiopian family. And actor Fredric Michaels wears a kente mask that reflects his African heritage. Camouflage masks are commonly used. An outdoor man dressed in camouflage from head to toe in a mask to match. A construction worker chooses camouflage, and two of her friends, Samantha Fernandez and Unique Corella, wear matching blue camouflage masks. Senior citizen Doris Shapiro wears an orange sequined mask and hat. The bright colors match her view: “I want to dance. I want to have fun, “he said.

Kai Waithe, in a fuchsia mask and purple hair extensions posing for a portrait: “I think being a creative person, through music and speech, and living in NYC has helped me with my fashion sense. I only wear what I feel, “he said. Retired Gil Gainey, who worked for many years in the human resources department at the hospital, wearing a paisley mask: “I’m very health conscious,” he said. We don’t know when this will go away, so we’d better be fashionable. “Teacher Amanda Clarke rushes to Brooklyn high school with a message on her mask, and on the minds of many people:” CHOOSE! “

(This story has been published from a wire agency feed with no modifications to the text. Only the title has been changed.)

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How COVID-19 affects the nervous system | Instant News


A new paper published in the journal JAMA Neurology in May 2020 discussed the presentation and complications of COVID-19 with respect to the nervous system.

The COVID-19 pandemic has caused hundreds of thousands of cases of severe pneumonia and respiratory disorders, in 188 countries and regions in the world. The causative agent, SARS-CoV-2, is a new coronavirus, with well-recognized lung complications. However, evidence is increasing that the virus also affects other organs, such as the nervous system and heart.

The Coronaviruses: A Glimpse

That corona virus is a group of large spread RNA viruses that infect animals and humans. Human infections are known to be caused by 7 coronaviruses, namely human coronavirus (HCoV) –229E, HCoV-NL63, HCoV-HKU1, HCoV-OC43, MERS-CoV, SARS-CoV-1, and SARS-CoV-2.

Among these, the last three are known to cause severe human disease. While HCoV is more associated with respiratory manifestations, three of them are known to infect neurons: HCoV-229E, HCoV-OC43, and SARS-CoV-1.

Current research aims to contribute to the knowledge of the SARS-CoV-2 neurotropism, as well as post-infectious neurological complications. This virus infects humans through ACE2 receptors in various tissues, including airway epithelium, kidney cells, small intestine, proper lung tissue, and endothelial cells.

Because endothelium is found in blood vessels throughout the body, this offers a potential route for CoV to be localized in the brain. In addition, a recent report shows that ACE2 is also found in brain neurons, astrocytes, and oligodendrocytes, especially in areas such as substantia nigra, ventricles, middle temporal gyrus, and olfactory bulb.

Interestingly, ACE2 in neuron tissue is expressed not only on the surface but also in the cytoplasm. This finding could imply that SARS-CoV-2 can infect neuronal and glial cells in all parts of the central nervous system.

How does neuroinvasion occur with SARS-CoV-2?

Current knowledge indicates the possibility of nerve cell virus invasion by several mechanisms. These include the transfer of viruses across synapses of infected cells, entering the brain through the olfactory nerve, infection of endothelial blood vessels, and migration of infected white blood cells across the blood-brain barrier (BBB).

The corona virus has been shown to spread back along the nerves from the edge of the peripheral nerves, across synapses, and thus into the brain, in several small animal studies. This is facilitated by a pathway for endocytosis or exocytosis between motor cortex neurons, and other secretory vesicular pathways between neurons and satellite cells.

Axonal transport occurs rapidly using axonal microtubules, which allow the virus to reach the body of neuron cells with a retrograde version of this mechanism.

The possibility of spreading the olfactory route is marked by the occurrence of isolated anosmia and age. In such cases, the virus can pass through the latticed plate to enter the central nervous system (CNS) of the nose. However, more recent unpublished research shows that olfactory neurons lack ACE2, whereas cells in the olfactory epithelium do so. This could mean that a viral injury to the olfactory epithelium, and not the olfactory neuron, is responsible for anosmia, but further studies will be needed to confirm this.

Cross the BBB

This virus can also pass through the BBB through two separate mechanisms. In the first case, infected vascular endothelial cells can move the virus across blood vessels to neurons. Once there, the virus can start to bud and infect more cells.

The second mechanism is through infected white blood cells that pass through the BBB – a mechanism called Trojan horse, which is famous for its role in HIV. Inflamed BBB allows the entry of immune cells and cytokines, and even, possibly, viral particles into the brain. T-lymphocytes, however, do not allow viruses to replicate even though they can be infected.

Neurological features of COVID-19

From limited data on neurological manifestations related to COVID-19, it is clear that headaches, anosmia, and age are among the most common symptoms. However, other findings include stroke and an abnormal state of consciousness.

While headaches occur in up to one third of confirmed cases, anosmia or age shows a much more varied prevalence. In Italy, about one fifth of cases show this symptom, while almost 90% of patients in Germany have such symptoms.

The researchers said, “Given the reports of anosmia that appear as early symptoms of COVID-19, specific testing for anosmia can offer the potential for early detection of COVID-19 infection.”

Impaired consciousness can occur in up to 37% of patients, due to various mechanisms such as infection and direct brain injury, metabolic-toxic encephalopathy, and demyelinating disease. Encephalitis has not been documented as a result of COVID-19.

Toxic-metabolic encephalopathy can occur due to a number of disorders of metabolic and endocrine function. These include electrolyte and mineral imbalances, kidney disorders, and cytokine storms, hypo or hyperglycemia, and liver dysfunction. Patients who are elderly, ill, or already have symptoms of dementia, or are malnourished, are at higher risk for this condition.

Less common neurological complications include Guillain-Barre syndrome, which is a post-viral acute inflammatory demyelinating disease, and cerebrovascular events, including stroke.

Is COVID-19 Therapy Related to Neurological Manifestations?

Nowadays, many different drugs are used to treat this condition.

Chloroquine and hydroxychloroquine, for example, can cause psychosis, peripheral neuropathy, and the latter can worsen the symptoms of myasthenia gravis. Tocilizumab, an IL-6 blocker, is intended to reduce excessive cytokine release that occurs in severe inflammation. Although admission to CNS is limited, it can sometimes cause headaches and dizziness.

Precautions for COVID-19 Patients with Neurological Conditions

If a patient already has a neurological condition that requires special treatment, they tend to be at higher risk for COVID-19, due to existing lung, heart, or liver conditions, having kidney disease (dialysis), if they are overweight, or at immunosuppressive drugs. Also, it is likely that they may be in nursing homes, where many countries have reported severe outbreaks.

This study concludes: “Doctors must continue to monitor patients closely for neurological diseases. Early detection of neurological deficits can lead to improved clinical outcomes and better treatment algorithms. “

Journal reference:

  • Zubair, A. S. et al. (2020). Neuropathogenesis and Neurological Manifestations of Coronavirus in the Coronavirus Era 2019: Overview. JAMA Neurology. doi: 10.1001 / jamaneurol.2020.2065.

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California will Reveal Guidelines that Allow Some Businesses to Reopen – NBC Los Angeles | Instant News


Business owners across California are anxiously awaiting Thursday’s new guidelines from Governor Gavin Newsom, which will outline broad changes to home stay orders across the state that close most retail stores to slow the spread of the corona virus.

Newsom is expected to allow businesses such as clothing stores, flower shops, bookstores and sporting goods stores to open their doors for the first time in almost two months, with some restrictions. The governor said the order would not cover other close contact businesses, such as eating in restaurants and hair salons. However, he also said some local governments could accept variants.

Guidelines for Reopening the White House Leave Room for Interpretation

For countries considering raising quarantine measures, official guidelines recommend a COVID-19 trajectory down in two weeks or a downward trajectory of a positive test as a percentage of the total test.

As shown below, when you compare the number of new cases yesterday with those from two weeks ago, the numbers are often lower, simply because the numbers fluctuate. Criteria has been criticized by some for being unclear, creating opportunities for any governor to argue that the numbers are good enough to start reopening.

Since home stay orders were issued on March 19, more than 4 million people have been removed from work in the most populous state.

The guidelines are part of Newsom’s four-step plan to reopen the country. Thursday will be phase two. The next phase, which can reopen salons, gymnasiums, cinemas and private church services, can be in a few months. Phase four will end all barriers and allow large meetings at concerts and sporting events.

The Newsom administration is tracking six indicators to determine when to reduce restrictions. They include the ability of the state to test people for COVID-19 and track who might be exposed to it and the capacity of hospitals to deal with potential spikes in new cases.

So far, Newsom said the country was on track to fulfill its objectives.

How Long Until Coronavirus Will Cause Use Of Top Hospitals Across The Country

This interactive chart uses the data model provided by Institute of Health Metrics and Evaluation to predict how coronavirus will affect health care resources in various countries. The maximum use of hospital beds in some states, such as New York, has passed while in others stay a few more weeks. Most states have enough public hospitals and ICU beds to meet demand, according to additional data from The Associated Press.

Newsom’s orders have been universally accepted today.

But three northern California states with few confirmed COVID-19 cases have allowed businesses to reopen. Tiny Modoc County allowed the only cinema to open its doors. Yuba and Sutter districts allowed in-store shopping and restarted fitness centers and fitness studios, salons, spas and tattoo rooms, libraries and playgrounds.

General Manager of Yuba Sutter Mall Natasha Shelton said about 18 of about 50 stores were open Wednesday and an estimated 200 people were inside during the day. Mall has reduced hours to allow for additional overnight cleaning. Tables in the food court are 6 feet apart and food trays are prohibited.

Newsom has cracked down on rogue counties before, ordering the temporary closure of all beaches in Orange County after several local governments refused to close it or impose public health restrictions. He lifted several orders after negotiating with the local government.

In Los Angeles, regional official outlining a plan that allows some reopening starting Friday, provided safety precautions are taken. Golfers can find the link again, and the trail will open with regional employees ready to remind pedestrians of the rules of social distance, said Chair of the Board of Trustees Kathryn Barger.

Some retailers in Los Angeles County can reopen with only roadside pickups – including florists and stores that sell toys, books, clothing, sporting goods and music. The district, the largest state with 10 million inhabitants, has caused more than half more than 2,500 deaths from the California virus.

California is no. 1 destination for travelers in the United States and coronavirus has ill status. Angie Crouch reports on NBC4 News at 5 pm on Wednesday, May 6, 2020.

For most people, new coronaviruses cause mild or moderate symptoms, such as fever and cough that go away in two to three weeks. For some people, especially older adults and people with existing health problems, can cause more severe illnesses, including pneumonia and death.

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Battle of Coronavirus A Mother and Child – NBC Los Angeles | Instant News


Glenda Johnson sat on her mother’s hospital bed, took her hand and told her that she could leave.

But Linda Hopkins, her face tense with pain due to coronavirus-related pneumonia, was not ready.

“I don’t want to die,” Linda, 83, answered, the tube putting oxygen into her nostrils, then her daughter remembered. “Very painful.”

Both of them had a beautiful life in Detroit, as close as a mother and child, NBC News report. They live together, travel together, shop together, worship together, party together. When the two of them fell ill at the end of March, they drove together to Beaumont Hospital near Royal Oak, where they tested positive COVID-19. They ended up in the same room, where they fought the disease together. Glenda, Linda’s only child, watched her mother’s last moments.

“I have no husband, no children, no brothers and sisters. My mother is the only one I have in the world,” Glenda said in a recent interview. “Now my heart is broken.”

Read the full story at NBCNews.com

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