Tag Archives: SYMPTOMS

The Californian variant is more contagious, generates worse symptoms, and may refuse vaccines | Instant News

Random variation is an essential component of all living things. It encourages diversity, and that’s why there are so many different species. Viruses are no exception. Most viruses are experts at changing the genome to adapt to their environment. We now have evidence that the virus that causes Covid, SARS-CoV-2, is not only changing but also significant. This is the twenty-fourth in a series of articles on how viruses change and what they mean for humanity. Read the rest: part one, The second part, Third part, part four, part five, section six, section seven, section eight, section nine, section ten, section eleven, part twelve, section thirteen, section fourteen, section fifteen, section sixteen, section seventeen, section eighteen, section nineteen, section twenty, section twenty one, part twenty two, and section twenty three.

When the SARS-CoV-2 variants developed mutations, they increased their ability to spread, make sick, and fight antibodies, resulting in more tougher cases of Covid-19. Earlier this month, I detailed one of the variants that started circulating in Southern California (B.1.427 / 429). In the weeks since then, the spread of the virus has been predictable, and the most recent data describing its structure and spread echoes the dangers I fear transmit to people in California, the United States, and the world at large.

To refresh, the viral strain was first described by a genome sequencing attempt from Cedars Sinai Hospital in Los Angeles. From their variant surveillance efforts, they have been tracking the dangerous strain of SARS-CoV-2 since July 2020. In the months since then, B.1.427 / 429 has spread among the population to more than half of the isolates analyzed in California in recent times . January. We postulated that their different mutations – S13I, W152C, and L452R – would result in higher transmissibility and increased antibody resistance, similar to the strains of Great Britain, South Africa and Brazil. This mutation and other mutations are depicted in the image below. I am talking in more detail about individual mutations and their functions here.

Looks like our fears are manifested. New data announced by Dr. Charles Chiu of the University of California San Francisco demonstrates B.1.427 / 429’s destructive abilities in detail. The study, according to Chiu, will be published in the future day. Samples collected from a number of California states showed 19 to 24% more variants were transmissible. One elderly care facility experienced an almost six-fold increase in transmission from the previous virus.

In addition, it appears that viral load has also increased among patients. Compared with individuals infected with the non-B.1.427 / 429 version of the virus, those infected with the California variant were measured viral load about twice as high. A greater viral load has some dire implications. First, people who are infected are much more likely to experience severe symptoms or symptoms in general. Second, they may have a longer duration of infection, shown in a study of a group of NBA basketball players player. Third, they have a greater chance of infecting other people, because every sneeze, cough and breath carries a larger proportion of virus particles.

As expected, the mutation in B.1.427 / 429 conferred a significant level of antibody resistance, both for natural antibodies from previous infection, and those given by vaccination. Much of this can be attributed to the L452R mutation alone, which is located in the receptor-binding domain: the mechanism that connects to the ACE2 receptor in human cells. One version of the virus called CAL.20A which only underwent this mutation saw an infectivity rate that was 40% higher than the common B.1.427 / 429 strain and 200% higher than the initial wild-type virus in the cohort. gorilla at the San Diego Zoo.

Further research from the San Francisco study showed increased virulence as well. In line with observed increases in viral load, the investigators found a 21% increase in ICU admissions and an eleven-fold increase in mortality among those infected with B.1.427 / 429.

However, spike protein may not be the only source of this embarrassing data. Various mutations outside of the spike protein can lead to increased immune escape, transmission, and virulence as well. Among these mutations are the T114I and S385T point mutations in non-structural protein 4, which is a transmembrane protein. Changes to this mechanism can increase immune escape, which this breed exhibits. Mutation of P323L into non-structural protein 12, which is present in many strains such as the UK, South Africa, Brazil and many more in the US, is involved in transcription. Mutations in this mechanism are likely to increase viral load resulting in transmission and virulence. The various mutations outside the spike protein are depicted in the image below.

These numbers are staggering. They describe the full power of the variant. In a matter of months, B.1.427 / 429 grew from one isolate to more than half the cases in the state. Undoubtedly, this variant has spread along the Pacific coast to the continental United States. We find ourselves in battle against an emerging horde of strains, all equipped with advanced weaponry: immune escapes, increased virulence and greater contagion. We have to upgrade our tools too with stronger public health efforts, variant surveillance, and maybe an adaptive vaccine if we are to win this war.


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United Kingdom Announces Plans to Get Out of Covid-19 Lockdown by Summer | Instant News

Prime Minister of England Boris Johnson has announced a scientific data-driven plan to finally lift it tight corona virus European country lockdowns.

The first step is to reopen the school on March 8, while recreation in an outdoor public area will be allowed between two people. As of March 29, people will no longer be legally required to stay at home but will be advised to continue working from home. Additionally, outdoor gatherings of two or six households will be permitted.

The second step next would be to lift restrictions on non-essential shops, hairdressers and other businesses, which are slated to reopen from April 12. On June 21, the UK believes they can end all legal restrictions on mixing and reopen the last high-risk stores. business like a nightclub.

“Today, I will set a road map to get us out of lockdown with caution,” Johnson said in a statement, adding that the gradual easing of restrictions must be phased in to avoid a surge in a new wave of infections.

“Our priority is always to bring children back to school which we know is very important for their education as well as their mental and physical well-being, and we will also prioritize ways for people to reunite with loved ones safely.”

This country has full national status kuncitara since January 4, after the new, more transmissible variant Corona virus is found in southeastern England. Previous reports stated that the mutant virus, also known as B.1.1.7, was about 45 percent more infectious and infectious 70 percent deadlier.

The new strain is now responsible for the majority of new infections in Great Britain.

“Our decisions will be made based on the latest data every step of the way, and we will be careful about this approach so we don’t undo the progress we’ve made so far and the sacrifices each of you have made to keep yourself and the others safe,” added Johnson.

Britain has been one of the hardest-hit countries from the ongoing pandemic, with the fourth-highest number of infections after the United States, India and Brazil.

To date, the country has witnessed more than four million cases and one hundred and twenty thousand related deaths, according to latest data compiled by Johns Hopkins University.

In recent weeks, health experts have warned that variant B.1.1.7 could become the dominant strain in the United States over the next month. According to a study conducted by a group of scientists led by the Scripps Research Institute, confirmed cases of the British coronavirus strain now doubled approximately every ten days in the United States.

Ethen Kim Lieser is a Minneapolis-based Science and Technology Editor who served at Google, The Korea Herald, Lincoln Journal Star, AsianWeek, and Arirang TV. Follow or call him on LinkedIn.

Image: Reuters


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New COVID Strains Bring More Symptoms, More Infections | Instant News

The South African variant contains a mutation that allows the virus to avoid some of the antibodies produced through the vaccine, said the CDC. Early studies suggest that the current COVID-19 vaccine may be less effective against the strain, although it still provides some protection.

Vaccine maker Moderna and Pfizer-BioNTech have announced that they are working to modify their vaccines – and possibly to create booster shots – to better protect against the South African variant.

The strain first identified in Brazil was found in only one US case – in Minnesota – and the person had recently traveled to Brazil, health officials said. There is some evidence to suggest that it may also be able to avoid antibodies.

Vaccine launches are key to stopping mutations

Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, said at a press conference that getting the COVID-19 vaccine out quickly is important to reduce the spread of the variant which is still rare.

The longer the virus is allowed to reproduce, the more mutations will develop.

“Getting people vaccinated as quickly and efficiently as possible will always be the best way to prevent further evolution of any mutants,” said Fauci. “When you do, you prevent replication, and replication is essential for mutation.”

Apart from getting the vaccine, the best way to protect yourself from the new variant is to keep doing it follow the same precautions what protects against the real coronavirus: Wear a mask (consider duplicating it), wash your hands, practice social distancing, avoid crowds, and stay at home if you can.


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Swiss- Covid: Feeling of losing control exacerbates mental illness | Instant News

(MENAFN – Swissinfo) Two-thirds of mentally ill women and half of mentally ill men report symptoms that worsened during the first wave of Covid-19, according to a global study with participation from the University of Zurich.

This content is published on 24 December 2020-12: 11 24 December 2020-12: 11 Keystone-SDA / ts

The feeling of losing control during a pandemic becomes a burden for patients. They are also deeply affected by a lack of social interaction and dissatisfaction with government actions regarding the coronavirus, the researchers wrote in the journal. Frontiers in Psychiatry .

In the spring, an international team led by Ali Jawaid, who works at the University of Zurich and is now conducting research at the Polish Braincity Institute, conducted an online survey of 2,734 existing mental illness patients from 12 countries.



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Bengaluru: Facilities refuse to rub those without symptoms | Bengaluru News | Instant News

BENGALURU: Although the government’s top priority is increasing testing, many Bengalis have alleged that the city’s primary health center (PHC) refuses to collect swab sample for testing if it doesn’t show up symptoms to Covid-19 infection.
Vijayanath S, a resident of Rajarajeshwari Nagar, visited a puskesmas located near Global Village on Sunday to look for a Covid-19 test, but swab collector refused to take his sample, claiming he was asymptomatic.

“I feel tired and want to check if I have Covid-19, but the swab officer at the Puskesmas refused to say I didn’t suffer fever, cough or runny nose, ”said Vijayanath. The collector said that I would just be wasting valuable testing resources.
A similar incident happened to Imran Khan at the Kengeri Health Center. “I feel a little feverish,” said Khan, a Kengeri resident. “The swab collector asks me if I have any major symptoms. When I told him I had a fever he said because it was ‘just a fever’, no tests were needed and suggested I take the Dolo-650 tablet. If BBMP can’t force testing, why promote it? Where do we go to get tested? What if symptoms get worse? ”
When questioned, a swab collector in Rajarajeshwari Nagar PHC said: “Why should we get rid of the antigen quickly or RT-PCR test kit when we are sure there is no infection? Of the 150 tests we do every day, over 95% are negative. We are wasting time and resources. ”
He went on to say, “We haven’t been paid for four months now, but we are working diligently. We know who might be positive and who isn’t. So we don’t do unnecessary tests. ”
A swab collector at a puskesmas in Jayanagar said they had been instructed by health department officials don’t do the test if the person is asymptomatic. “We are only following orders from senior officials. They told us to do the RT-PCR test only for those who showed symptoms, “he said.
TOI called 21 puskesmas across the city and the swab collectors at these facilities confirmed that they did not perform the RAT or RT-PCR tests for those who did not show any symptoms.
However, when contacted, N Manjuantha Prasad, Commissioner of the BBMP, admitted that he did not know that anyone without symptoms had been refused the test and promised to investigate. He said he would take action against those who did not carry out the test.
“All staff have been ordered to test all who come to the Puskesmas. No test can be rejected. It is not true that someone did it, ”said Prasad.


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